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dc.contributor.authorStylianopoulos, T.en
dc.creatorStylianopoulos, T.en
dc.date.accessioned2019-05-06T12:24:39Z
dc.date.available2019-05-06T12:24:39Z
dc.date.issued2016
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48848
dc.description.abstractThe rationale for the use of nanoparticle formulations to treat cancer is based on the ability of these particles to facilitate selective delivery of drugs to the tumor site, reducing adverse effects and improving therapeutic outcomes. Current clinically approved nanomedicines have managed to reduce adverse effects significantly but the increase in overall survival is modest in many cases. Therefore, even though the goal of a better quality of life for the cancer patients has been achieved in large part, the increase in life expectancy still remains a critical challenge. Abnormalities in the tumor micro-environment prevent homogeneous distribution of nanoparticles to the interior of the tumor, decreasing the efficacy of the drug. Intelligent drug delivery systems offer new hope for overcoming these physiological barriers posed by the tumor and have the potential to provide more effective treatments. This review discusses the barriers to the delivery of nanomedicines to solid tumors, suggests design considerations that could optimize delivery and reviews promising intelligent drug delivery systems that have been developed to date. © 2016 by De Gruyter.en
dc.language.isoengen
dc.sourceEuropean Journal of Nanomedicineen
dc.subjectReviewen
dc.subjectantineoplastic agenten
dc.subjecthumanen
dc.subjectcancer patienten
dc.subjectcancer survivalen
dc.subjectdrug efficacyen
dc.subjectoverall survivalen
dc.subjecttumor microenvironmenten
dc.subjectsolid tumoren
dc.subjectnonhumanen
dc.subjectquality of lifeen
dc.subjectenzymeen
dc.subjectlife expectancyen
dc.subjectDesignen
dc.subjectTumorsen
dc.subjectDiseasesen
dc.subjectMicroenvironmentsen
dc.subjectnanomedicineen
dc.subjectnanoparticleen
dc.subjectNanoparticlesen
dc.subjectdrug designen
dc.subjectpHen
dc.subjectMedical nanotechnologyen
dc.subjectcancer nanomedicineen
dc.subjectCritical challengesen
dc.subjectdesign considerationsen
dc.subjectdrug delivery barriersen
dc.subjectDrug delivery systemen
dc.subjectHomogeneous distributionen
dc.subjectLife expectanciesen
dc.subjectNanoparticle formulationen
dc.subjectTherapeutic outcomesen
dc.subjecttumor micro-environmenten
dc.titleIntelligent drug delivery systems for the treatment of solid tumorsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1515/ejnm-2015-0041
dc.description.volume8
dc.description.startingpage9
dc.description.endingpage16
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.description.totalnumpages9-16


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