dc.contributor.author | Antoniades, Ioanna | en |
dc.contributor.author | Stylianou, Panayiota | en |
dc.contributor.author | Skourides, Paris A. | en |
dc.creator | Antoniades, Ioanna | en |
dc.creator | Stylianou, Panayiota | en |
dc.creator | Skourides, Paris A. | en |
dc.date.accessioned | 2019-11-04T12:50:12Z | |
dc.date.available | 2019-11-04T12:50:12Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1534-5807 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/52924 | |
dc.description.abstract | Cilia have been associated with diverse developmental and physiological processes, and defects in cilia underlie a number of genetic conditions. Several lines of evidence support a critical role of the actin cytoskeleton in ciliogenesis and ciliary function. Here, we show that well-characterized focal adhesion (FA) proteins, including FAK, Paxillin, and Vinculin, associate with the basal bodies of multiciliated cells and form complexes (CAs) that interact with the actincytoskeleton. FAK downregulation leads to ciliogenesis defects similar to those observed when the actin cytoskeleton is disrupted, including defects in basal body migration, docking, and spacing, suggesting that CAs link basal bodies to the actin cytoskeleton. The important role of FA proteins in ciliogenesis leads us to propose that evolutionarily FA proteins, many of which are found in primitive flagellated unicellular eukaryotes, may have originally evolved to perform functions at flagella and were laterco-opted for use in cell adhesion. © 2014 Elsevier Inc. | en |
dc.source | Developmental Cell | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892381509&doi=10.1016%2fj.devcel.2013.12.003&partnerID=40&md5=2e46c327f1e27e06f6d0356b08d48436 | |
dc.subject | article | en |
dc.subject | adult | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | priority journal | en |
dc.subject | pathogenesis | en |
dc.subject | unclassified drug | en |
dc.subject | down regulation | en |
dc.subject | nonhuman | en |
dc.subject | protein | en |
dc.subject | phenotype | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal experiment | en |
dc.subject | animal tissue | en |
dc.subject | messenger RNA | en |
dc.subject | cell migration | en |
dc.subject | Cilia | en |
dc.subject | extracellular matrix | en |
dc.subject | Down-Regulation | en |
dc.subject | complex formation | en |
dc.subject | carboxy terminal sequence | en |
dc.subject | embryo | en |
dc.subject | Xenopus | en |
dc.subject | actin filament | en |
dc.subject | Basal Bodies | en |
dc.subject | cell adhesion | en |
dc.subject | ciliary motility | en |
dc.subject | ciliogenesis | en |
dc.subject | eukaryotic flagellum | en |
dc.subject | Focal Adhesion Protein-Tyrosine Kinases | en |
dc.subject | kinetosome | en |
dc.subject | paxillin | en |
dc.subject | Actin Cytoskeleton | en |
dc.subject | cell polarity | en |
dc.subject | cellular distribution | en |
dc.subject | ciliated epithelium | en |
dc.subject | cytosol | en |
dc.subject | eukaryote | en |
dc.subject | Fak protein | en |
dc.subject | flagellum | en |
dc.subject | focal adhesion | en |
dc.subject | focal adhesion kinase | en |
dc.subject | molecular docking | en |
dc.subject | NIH 3T3 Cells | en |
dc.subject | physiological process | en |
dc.subject | Protein Binding | en |
dc.subject | Protista | en |
dc.subject | talin | en |
dc.subject | vinculin | en |
dc.title | Making the Connection: Ciliary Adhesion Complexes Anchor Basal Bodies to the Actin Cytoskeleton | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.devcel.2013.12.003 | |
dc.description.volume | 28 | |
dc.description.startingpage | 70 | |
dc.description.endingpage | 80 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :25</p> | en |
dc.source.abbreviation | Dev.Cell | en |
dc.contributor.orcid | Skourides, Paris A. [0000-0003-3502-5729] | |
dc.gnosis.orcid | 0000-0003-3502-5729 | |