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dc.contributor.authorApidianakis, Yiorgosen
dc.contributor.authorGrbavec, D.en
dc.contributor.authorStifani, S.en
dc.contributor.authorDelidakis, Christosen
dc.creatorApidianakis, Yiorgosen
dc.creatorGrbavec, D.en
dc.creatorStifani, S.en
dc.creatorDelidakis, Christosen
dc.date.accessioned2019-11-04T12:50:13Z
dc.date.available2019-11-04T12:50:13Z
dc.date.issued2001
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/52932
dc.description.abstractGroucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes ranging from sex determination to embryonic patterning and neuroblast specification. We have characterized a function of Gro in imaginal development, namely the repression of hedgehog (hh) in anterior wing pouch cells. hh encodes a secreted morphogen with potent patterning activities. In Drosophila thoracic appendages (legs, wings, halteres), hh is expressed in posterior compartments and induces the anteroposterior (AP) pattern organizer in the cells across the AP boundary. hh is repressed in anterior compartments at least partly via Ci[rep], a form of the multifunctional transcription factor Cubitus interruptus (Ci). We show that cells in the wing primordium close to the AP boundary need gro activity to maintain repression of hh transcription, whereas in more anterior cells gro is dispensable. This repressive function of Gro does not appear to be mediated by Ci[rep]. Analysis of mutant gro transgenes has revealed that the Q and WD40 domains are both necessary for hh repression. Yet, deletion of the WD40 repeats does not always abolish Gro activity. Our findings provide new insights both into the mechanisms of AP patterning of the wing and into the function of Gro.en
dc.sourceDevelopmenten
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0035168543&partnerID=40&md5=c406ed43d16f330b778a992225c86948
dc.subjectarticleen
dc.subjectpriority journalen
dc.subjectprotein expressionen
dc.subjectunclassified drugen
dc.subjectnonhumanen
dc.subjectAnimalsen
dc.subjectHedgehogen
dc.subjectsonic hedgehog proteinen
dc.subjecttranscription factoren
dc.subjectTranscription Factorsen
dc.subjectDNA-Binding Proteinsen
dc.subjectgene deletionen
dc.subjectregulatory mechanismen
dc.subjectmutationen
dc.subjectthoraxen
dc.subjectErinaceidaeen
dc.subjectprotein domainen
dc.subjectAnimals, Genetically Modifieden
dc.subjectanterior posterior axisen
dc.subjectBasic Helix-Loop-Helix Transcription Factorsen
dc.subjectCo-repressoren
dc.subjectCubitusen
dc.subjectCubitus interruptusen
dc.subjectCubitus interruptus transcription factoren
dc.subjectDrosophilaen
dc.subjectDrosophila Proteinsen
dc.subjectembryo pattern formationen
dc.subjectforelimben
dc.subjectGene Expression Regulation, Developmentalen
dc.subjectgene repressionen
dc.subjectGrouchoen
dc.subjectgroucho proteinen
dc.subjectInsect Proteinsen
dc.subjectLarvaen
dc.subjectmorphogenen
dc.subjectneuroblasten
dc.subjectRepressionen
dc.subjectrepressor proteinen
dc.subjectRepressor Proteinsen
dc.subjectsex determinationen
dc.subjecttransgeneen
dc.subjectWingen
dc.subjectWing patterningen
dc.titleGroucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouchen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume128
dc.description.startingpage4361
dc.description.endingpage4370
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :13</p>en
dc.source.abbreviationDevelopment (Cambridge)en
dc.contributor.orcidApidianakis, Yiorgos [0000-0002-7465-3560]
dc.gnosis.orcid0000-0002-7465-3560


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