dc.contributor.author | Constantinou, Andreas I. | en |
dc.contributor.author | White, B. E. P. | en |
dc.contributor.author | Tonetti, D. | en |
dc.contributor.author | Yang, Y. | en |
dc.contributor.author | Liang, W. | en |
dc.contributor.author | Li, W. | en |
dc.contributor.author | Van Breemen, R. B. | en |
dc.creator | Constantinou, Andreas I. | en |
dc.creator | White, B. E. P. | en |
dc.creator | Tonetti, D. | en |
dc.creator | Yang, Y. | en |
dc.creator | Liang, W. | en |
dc.creator | Li, W. | en |
dc.creator | Van Breemen, R. B. | en |
dc.date.accessioned | 2019-11-04T12:50:24Z | |
dc.date.available | 2019-11-04T12:50:24Z | |
dc.date.issued | 2005 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53007 | |
dc.description.abstract | The aim of this study was to determine how the efficacy of tamoxifen is affected when combined with soy isoflavones. To address this, female Sprague-Dawley rats were placed on diets supplemented with tamoxifen, genistein, daidzein, or a combination of each isoflavone with tamoxifen | en |
dc.description.abstract | a week later mammary tumours were induced by 7,12 dimethylbenzanthracene. The most effective diet was the tamoxifen/daidzein combination. It reduced tumour multiplicity by 76%, tumour incidence by 35%, tumour burden by over 95%, and increased tumour latency by 62% compared with positive controls. The tamoxifen/daidzein combination diet was in all aspects more effective while the tamoxifen/genistein combination was less effective than the tamoxifen diet. The tamoxifen/daidzein diet significantly decreased 8-oxo-deoxyguanosine levels (an indicator of oxidative DNA damage) in the mammary glands. This study conclusively shows for the first time the combination of daidzein with tamoxifen produces increased protection against mammary carcinogenesis, while the combination of genistein with tamoxifen produces an opposing effect when compared with tamoxifen alone. © 2004 Elsevier Ltd. All rights reserved. | en |
dc.source | European journal of cancer | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-14344253097&doi=10.1016%2fj.ejca.2004.12.005&partnerID=40&md5=4fbf95daadfd082875796e6e014f0544 | |
dc.subject | article | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | priority journal | en |
dc.subject | drug efficacy | en |
dc.subject | Breast cancer | en |
dc.subject | cancer incidence | en |
dc.subject | carcinogenesis | en |
dc.subject | cancer prevention | en |
dc.subject | Chemoprevention | en |
dc.subject | nonhuman | en |
dc.subject | enzyme blood level | en |
dc.subject | drug mechanism | en |
dc.subject | Drug Interactions | en |
dc.subject | Animals | en |
dc.subject | diet supplementation | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | animal tissue | en |
dc.subject | cell protection | en |
dc.subject | Tamoxifen | en |
dc.subject | breast tumor | en |
dc.subject | DNA damage | en |
dc.subject | isoflavone | en |
dc.subject | Isoflavones | en |
dc.subject | rat | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Antineoplastic Agents, Hormonal | en |
dc.subject | Equol | en |
dc.subject | Phytoestrogens | en |
dc.subject | Genistein | en |
dc.subject | Daidzein | en |
dc.subject | Mammary Neoplasms, Experimental | en |
dc.subject | 7,12 dimethylbenz[a]anthracene | en |
dc.subject | deoxyguanosine | en |
dc.subject | Dietary Supplements | en |
dc.subject | DMBA | en |
dc.subject | Hydrolysis | en |
dc.subject | mammary gland | en |
dc.subject | Soy | en |
dc.title | The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.ejca.2004.12.005 | |
dc.description.volume | 41 | |
dc.description.startingpage | 647 | |
dc.description.endingpage | 654 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :58</p> | en |
dc.source.abbreviation | Eur.J.Cancer | en |
dc.contributor.orcid | Constantinou, Andreas I. [0000-0003-0365-1821] | |
dc.gnosis.orcid | 0000-0003-0365-1821 | |