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dc.contributor.authorKrygier, A. E.en
dc.contributor.authorMurley, J. S.en
dc.contributor.authorMehta, R. R.en
dc.contributor.authorConstantinou, Andreas I.en
dc.date.accessioned2019-11-04T12:52:15Z
dc.date.available2019-11-04T12:52:15Z
dc.date.issued1997
dc.identifier.issn1019-6439
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53214
dc.description.abstractThe objective of the present study was to determine if genistein can induce human breast adenocarcinoma cell maturation. To gain understanding on its mechanism of action, we used estrogen receptor-positive (ER+) MCF-7, and ER-MDA-MB-468 cells. Treating these cells with genistein resulted in growth inhibition accompanied by increased cell maturation, which was evaluated by the production of casein and lipids. These maturation markers were optimally expressed after nine days of treatment with 30 μM of genistein. Since both ER+ and ER- cells became differentiated, we conclude that the ER is not a component of the genistein-initiated scheme of cellular differentiation.en
dc.sourceInternational journal of oncologyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0030898640&partnerID=40&md5=1b5bb6118837fa32bf89d0dd387ddb87
dc.subjectarticleen
dc.subjecthumanen
dc.subjectbreast canceren
dc.subjectcontrolled studyen
dc.subjectpriority journalen
dc.subjectDifferentiationen
dc.subjectestrogen receptoren
dc.subjectChemopreventionen
dc.subjecthuman cellen
dc.subjectcell differentiationen
dc.subjectantiestrogenen
dc.subjectdaidzeinen
dc.subjectIsoflavonesen
dc.subjectGenisteinen
dc.subjectTopoisomeraseen
dc.subjectProtein tyrosinase kinaseen
dc.titleInduction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic functionen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume10
dc.description.startingpage753
dc.description.endingpage757
dc.type.uhtypeArticleen
dc.description.notes<p>Manufacturers: indofine, United Statesen
dc.description.notesCited By :7</p>en
dc.source.abbreviationInt.J.Oncol.en
dc.contributor.orcidConstantinou, Andreas I. [0000-0003-0365-1821]


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