dc.contributor.author | Molina-Serrano, D. | en |
dc.contributor.author | Schiza, V. | en |
dc.contributor.author | Demosthenous, Christis | en |
dc.contributor.author | Stavrou, Emmanouil | en |
dc.contributor.author | Oppelt, J. | en |
dc.contributor.author | Kyriakou, DImitris | en |
dc.contributor.author | Liu, W. | en |
dc.contributor.author | Zisser, G. | en |
dc.contributor.author | Bergler, H. | en |
dc.contributor.author | Dang, W. | en |
dc.contributor.author | Kirmizis, Antonis | en |
dc.creator | Molina-Serrano, D. | en |
dc.creator | Schiza, V. | en |
dc.creator | Demosthenous, Christis | en |
dc.creator | Stavrou, Emmanouil | en |
dc.creator | Oppelt, J. | en |
dc.creator | Kyriakou, DImitris | en |
dc.creator | Liu, W. | en |
dc.creator | Zisser, G. | en |
dc.creator | Bergler, H. | en |
dc.creator | Dang, W. | en |
dc.creator | Kirmizis, Antonis | en |
dc.date.accessioned | 2019-11-04T12:52:22Z | |
dc.date.available | 2019-11-04T12:52:22Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1469-221X | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53256 | |
dc.description.abstract | Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with specific alterations in histone modifications that subsequently affect lifespan remains elusive. We show here that deletion of histone N-alpha-terminal acetyltransferase Nat4 and loss of its associated H4 N-terminal acetylation (N-acH4) extend yeast replicative lifespan. Notably, nat4Δ-induced longevity is epistatic to the effects of calorie restriction (CR). Consistent with this, (i) Nat4 expression is downregulated and the levels of N-acH4 within chromatin are reduced upon CR, (ii) constitutive expression of Nat4 and maintenance of N-acH4 levels reduces the extension of lifespan mediated by CR, and (iii) transcriptome analysis indicates that nat4Δ largely mimics the effects of CR, especially in the induction of stress-response genes. We further show that nicotinamidase Pnc1, which is typically upregulated under CR, is required for nat4Δ-mediated longevity. Collectively, these findings establish histone N-acH4 as a regulator of cellular lifespan that links CR to increased stress resistance and longevity. © 2016 The Authors. Published under the terms of the CC BY 4.0 license | en |
dc.source | EMBO reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84996555033&doi=10.15252%2fembr.201642540&partnerID=40&md5=2158fe6e3ec65031df79b28c1599debb | |
dc.subject | controlled study | en |
dc.subject | priority journal | en |
dc.subject | Time Factors | en |
dc.subject | gene | en |
dc.subject | protein expression | en |
dc.subject | unclassified drug | en |
dc.subject | down regulation | en |
dc.subject | gene expression regulation | en |
dc.subject | nonhuman | en |
dc.subject | upregulation | en |
dc.subject | Article | en |
dc.subject | metabolism | en |
dc.subject | cell survival | en |
dc.subject | gene expression profiling | en |
dc.subject | genetics | en |
dc.subject | transcriptome | en |
dc.subject | physiology | en |
dc.subject | time factor | en |
dc.subject | Down-Regulation | en |
dc.subject | amino terminal sequence | en |
dc.subject | gene induction | en |
dc.subject | Saccharomyces cerevisiae | en |
dc.subject | protein processing | en |
dc.subject | epistasis | en |
dc.subject | Protein Processing, Post-Translational | en |
dc.subject | Histones | en |
dc.subject | deficiency | en |
dc.subject | Transcriptional Activation | en |
dc.subject | chromatin | en |
dc.subject | Gene Expression Regulation, Fungal | en |
dc.subject | histone | en |
dc.subject | Saccharomyces cerevisiae Proteins | en |
dc.subject | calorie restriction | en |
dc.subject | acetylation | en |
dc.subject | transcription initiation | en |
dc.subject | acyltransferase | en |
dc.subject | caloric restriction | en |
dc.subject | cellular stress response | en |
dc.subject | histone acetyltransferase | en |
dc.subject | Histone Acetyltransferases | en |
dc.subject | histone H4 | en |
dc.subject | histone N-terminal acetylation | en |
dc.subject | lifespan | en |
dc.subject | longevity | en |
dc.subject | N-Terminal Acetyltransferase D | en |
dc.subject | Nat4 | en |
dc.subject | nat4 gene | en |
dc.subject | Nat4 protein | en |
dc.subject | NAT4 protein, S cerevisiae | en |
dc.subject | nicotinamidase | en |
dc.subject | peptide alpha n acetyltransferase D | en |
dc.subject | Pnc1 | en |
dc.subject | Pnc1 protein | en |
dc.subject | PNC1 protein, S cerevisiae | en |
dc.subject | polysome | en |
dc.subject | protein acetylation | en |
dc.subject | ribosome DNA | en |
dc.subject | Saccharomyces cerevisiae protein | en |
dc.title | Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.15252/embr.201642540 | |
dc.description.volume | 17 | |
dc.description.startingpage | 1829 | |
dc.description.endingpage | 1843 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :2</p> | en |
dc.source.abbreviation | EMBO Rep. | en |
dc.contributor.orcid | Kirmizis, Antonis [0000-0002-3748-8711] | |
dc.gnosis.orcid | 0000-0002-3748-8711 | |