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Drug delivery innovations for enhancing the anticancer potential of vitamin e isoforms and their derivatives

dc.contributor.authorNeophytou, Christiana M.en
dc.contributor.authorConstantinou, Andreas I.en
dc.creatorNeophytou, Christiana M.en
dc.creatorConstantinou, Andreas I.en
dc.date.accessioned2019-11-04T12:52:24Z
dc.date.available2019-11-04T12:52:24Z
dc.date.issued2015
dc.identifier.issn2314-6133
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53270
dc.description.abstractVitamin E isoforms have been extensively studied for their anticancer properties. Novel drug delivery systems (DDS) that include liposomes, nanoparticles, and micelles are actively being developed to improve Vitamin E delivery. Furthermore, several drug delivery systems that incorporate Vitamin E isoforms have been synthesized in order to increase the bioavailability of chemotherapeutic agents or to provide a synergistic effect. D-alpha-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) is a synthetic derivative of natural alpha-tocopherol which is gaining increasing interest in the development of drug delivery systems and has also shown promising anticancer effect as a single agent. This review provides a summary of the properties and anticancer effects of the most potent Vitamin E isoforms and an overview of the various formulations developed to improve their efficacy, with an emphasis on the use of TPGS in drug delivery approaches. © 2015 Christiana M. Neophytou and Andreas I. Constantinou.en
dc.sourceBioMed Research Internationalen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84934932682&doi=10.1155%2f2015%2f584862&partnerID=40&md5=83a028253ab60f7cca03d8fc34b40aee
dc.subjectReviewen
dc.subjectantineoplastic agenten
dc.subjectAntineoplastic Agentsen
dc.subjecthumanen
dc.subjectNeoplasmsen
dc.subjectHumansen
dc.subjectdrug effecten
dc.subjectdrug efficacyen
dc.subjectantineoplastic activityen
dc.subjectnonhumanen
dc.subjectpathologyen
dc.subjectdrug mechanismen
dc.subjectdrug potentiationen
dc.subjectliposomeen
dc.subjectLiposomesen
dc.subjectmacrogolen
dc.subjectclinical evaluationen
dc.subjectchemistryen
dc.subjectdrug bioavailabilityen
dc.subjectdrug metabolismen
dc.subjectdrug formulationen
dc.subjectdrug delivery systemen
dc.subjectDrug Delivery Systemsen
dc.subjectanalogs and derivativesen
dc.subjectdrug distributionen
dc.subjectstructure analysisen
dc.subjectnanoparticleen
dc.subjectNanoparticlesen
dc.subjecttumor cell lineen
dc.subjectmicelleen
dc.subjectphysical chemistryen
dc.subjectintracellular transporten
dc.subjectCell Line, Tumoren
dc.subjectalpha tocopherolen
dc.subjectVitamin Een
dc.subjectalpha tocotrienolen
dc.subjecttocofersolanen
dc.subjectdrug potencyen
dc.subjectdrug structureen
dc.subjectalpha-Tocopherolen
dc.subjectbiological activityen
dc.subjectdrug industryen
dc.subjecteffective concentrationen
dc.subjectnanoencapsulationen
dc.subjectsuccinic aciden
dc.titleDrug delivery innovations for enhancing the anticancer potential of vitamin e isoforms and their derivativesen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1155/2015/584862
dc.description.volume2015
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :9</p>en
dc.source.abbreviationBioMed Res.Int.en
dc.contributor.orcidConstantinou, Andreas I. [0000-0003-0365-1821]
dc.gnosis.orcid0000-0003-0365-1821


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