dc.contributor.author | Panayidou, S. | en |
dc.contributor.author | Ioannidou, E. | en |
dc.contributor.author | Apidianakis, Yiorgos | en |
dc.creator | Panayidou, S. | en |
dc.creator | Ioannidou, E. | en |
dc.creator | Apidianakis, Yiorgos | en |
dc.date.accessioned | 2019-11-04T12:52:25Z | |
dc.date.available | 2019-11-04T12:52:25Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2150-5594 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53279 | |
dc.description.abstract | Drosophila has been the invertebrate model organism of choice for the study of innate immune responses during the past few decades. Many Drosophila-microbe interaction studies have helped to define innate immunity pathways, and significant effort has been made lately to decipher mechanisms of microbial pathogenesis. Here we catalog 68 bacterial, fungal, and viral species studied in flies, 43 of which are relevant to human health. We discuss studies of human pathogens in flies revealing not only the elicitation and avoidance of immune response but also mechanisms of tolerance, host tissue homeostasis, regeneration, and predisposition to cancer. Prominent among those is the emerging pattern of intestinal regeneration as a defense response induced by pathogenic and innocuous bacteria. Immunopathology mechanisms and many microbial virulence factors have been elucidated, but their relevance to human health conventionally necessitates validation in mammalian models of infection. © 2014 Landes Bioscience. | en |
dc.source | Virulence | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897906917&doi=10.4161%2fviru.27524&partnerID=40&md5=67c567f481c14ebde6af3c1f11034b95 | |
dc.subject | model | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | review | en |
dc.subject | nonhuman | en |
dc.subject | disease predisposition | en |
dc.subject | immune response | en |
dc.subject | innate immunity | en |
dc.subject | Animals | en |
dc.subject | Bacterial Infections | en |
dc.subject | Bacteria | en |
dc.subject | immunopathology | en |
dc.subject | Virus Diseases | en |
dc.subject | Staphylococcus aureus | en |
dc.subject | Pseudomonas aeruginosa | en |
dc.subject | Viruses | en |
dc.subject | Drosophila melanogaster | en |
dc.subject | Vibrio cholerae | en |
dc.subject | homeostasis | en |
dc.subject | Drosophila | en |
dc.subject | bacterium | en |
dc.subject | virus | en |
dc.subject | Enterococcus faecalis | en |
dc.subject | Francisella tularensis | en |
dc.subject | Fungi | en |
dc.subject | fungus | en |
dc.subject | Gram negative bacterium | en |
dc.subject | Gram positive bacterium | en |
dc.subject | Lactobacillus plantarum | en |
dc.subject | Listeria monocytogenes | en |
dc.subject | Models, Animal | en |
dc.subject | Mycobacterium marinum | en |
dc.subject | Mycoses | en |
dc.subject | organismal interaction | en |
dc.subject | Salmonella Typhimurium | en |
dc.subject | SalmonellaTyphimurium | en |
dc.subject | Serratia marcescens | en |
dc.title | Human pathogenic bacteria, fungi, and viruses in Drosophila | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.4161/viru.27524 | |
dc.description.volume | 5 | |
dc.description.startingpage | 253 | |
dc.description.endingpage | 269 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :19</p> | en |
dc.source.abbreviation | Virulence | en |
dc.contributor.orcid | Apidianakis, Yiorgos [0000-0002-7465-3560] | |
dc.gnosis.orcid | 0000-0002-7465-3560 | |