dc.contributor.author | Mojsilovic-Petrovic, J. | en |
dc.contributor.author | Nedelsky, N. | en |
dc.contributor.author | Boccitto, M. | en |
dc.contributor.author | Mano, I. | en |
dc.contributor.author | Georgiades, Savvas N. | en |
dc.contributor.author | Zhou, W. | en |
dc.contributor.author | Liu, Y. | en |
dc.contributor.author | Neve, R. L. | en |
dc.contributor.author | Taylor, J. P. | en |
dc.contributor.author | Driscoll, M. | en |
dc.contributor.author | Clardy, J. | en |
dc.contributor.author | Merry, D. | en |
dc.contributor.author | Kalb, R. G. | en |
dc.creator | Mojsilovic-Petrovic, J. | en |
dc.creator | Nedelsky, N. | en |
dc.creator | Boccitto, M. | en |
dc.creator | Mano, I. | en |
dc.creator | Georgiades, Savvas N. | en |
dc.creator | Zhou, W. | en |
dc.creator | Liu, Y. | en |
dc.creator | Neve, R. L. | en |
dc.creator | Taylor, J. P. | en |
dc.creator | Driscoll, M. | en |
dc.creator | Clardy, J. | en |
dc.creator | Merry, D. | en |
dc.creator | Kalb, R. G. | en |
dc.date.accessioned | 2019-11-21T06:21:33Z | |
dc.date.available | 2019-11-21T06:21:33Z | |
dc.date.issued | 2009 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55871 | |
dc.description.abstract | Aging is a risk factor for the development of adult-onset neurodegenerative diseases. Although some of the molecular pathways regulating longevity and stress resistance in lower organisms are defined (i.e., those activating the transcriptional regulators DAF-16 and HSF-1 in Caenorhabditis elegans), their relevance to mammals and disease susceptibility are unknown. We studied the signaling controlled by the mammalian homolog of DAF-16, FOXO3a, in model systems of motor neuron disease. Neuron death elicited in vitro by excitotoxic insult or the expression of mutant SOD1, mutant p150glued, or polyQ-expanded androgen receptor was abrogated by expression of nuclear-targeted FOXO3a. We identify a compound [Psammaplysene A (PA)] that increases nuclear localization of FOXO3a in vitro and in vivo and show that PA also protects against these insults in vitro. Administration of PA to invertebrate model systems of neurodegeneration similarly blocked neuron death in a DAF-16/FOXO3a-dependent manner. These results indicate that activation of the DAF-16/FOXO3a pathway, genetically or pharmacologically, confers protection against the known causes of motor neuron diseases. Copyright © 2009 Society for Neuroscience. | en |
dc.source | Journal of Neuroscience | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-67649366086&doi=10.1523%2fJNEUROSCI.1805-09.2009&partnerID=40&md5=b0b0877e8a87751c0b4c06c79011fbe4 | |
dc.subject | article | en |
dc.subject | Female | en |
dc.subject | controlled study | en |
dc.subject | priority journal | en |
dc.subject | male | en |
dc.subject | Computational Biology | en |
dc.subject | protein expression | en |
dc.subject | Immunohistochemistry | en |
dc.subject | nonhuman | en |
dc.subject | signal transduction | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | animal tissue | en |
dc.subject | mouse | en |
dc.subject | Fluorescence | en |
dc.subject | in vitro study | en |
dc.subject | Cell Culture Techniques | en |
dc.subject | in vivo study | en |
dc.subject | embryo | en |
dc.subject | Drosophila | en |
dc.subject | Cell Count | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Embryo, Mammalian | en |
dc.subject | Forkhead Transcription Factors | en |
dc.subject | rat | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Motor Neurons | en |
dc.subject | Blotting, Western | en |
dc.subject | Tyrosine | en |
dc.subject | androgen receptor | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Cell Death | en |
dc.subject | Excitatory Amino Acid Agonists | en |
dc.subject | excitotoxicity | en |
dc.subject | Kainic Acid | en |
dc.subject | motor neuron disease | en |
dc.subject | nerve cell necrosis | en |
dc.subject | nerve degeneration | en |
dc.subject | neuroprotection | en |
dc.subject | Neuroprotective Agents | en |
dc.subject | nuclear localization signal | en |
dc.subject | Spinal Cord | en |
dc.subject | transcription factor DAF 16 | en |
dc.subject | transcription factor FKHRL1 | en |
dc.title | FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1523/JNEUROSCI.1805-09.2009 | |
dc.description.volume | 29 | |
dc.description.issue | 25 | |
dc.description.startingpage | 8236 | |
dc.description.endingpage | 8247 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :52</p> | en |
dc.source.abbreviation | J.Neurosci. | en |
dc.contributor.orcid | Georgiades, Savvas N. [0000-0002-6106-9904] | |
dc.gnosis.orcid | 0000-0002-6106-9904 | |