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dc.contributor.authorBortolato, B.en
dc.contributor.authorHyphantis, T.en
dc.contributor.authorValpione, S.en
dc.contributor.authorPerini, G.en
dc.contributor.authorMaes, M.en
dc.contributor.authorMorris, G.en
dc.contributor.authorKubera, M.en
dc.contributor.authorKöhler, C. A.en
dc.contributor.authorFernandes, B. S.en
dc.contributor.authorStubbs, B.en
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorCarvalho, A. F.en
dc.creatorBortolato, B.en
dc.creatorHyphantis, T.en
dc.creatorValpione, S.en
dc.creatorPerini, G.en
dc.creatorMaes, M.en
dc.creatorMorris, G.en
dc.creatorKubera, M.en
dc.creatorKöhler, C. A.en
dc.creatorFernandes, B. S.en
dc.creatorStubbs, B.en
dc.creatorPavlidis, Nicholasen
dc.creatorCarvalho, A. F.en
dc.date.accessioned2018-06-22T09:52:37Z
dc.date.available2018-06-22T09:52:37Z
dc.date.issued2017
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41435
dc.description.abstractMajor Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic–pituitaryadrenal axis. Consequently, the prompt recognition of depression among patients with cancer who may benefit of treatment strategies targeting depressive symptoms, cognitive dysfunction, fatigue and sleep disturbances, is a public health priority. Moreover, behavioral strategies aiming at reducing psychological distress and depressive symptoms, including addressing unhealthy diet and life-style choices, as well as physical inactivity and sleep dysfunction, may represent important strategies not only to treat depression, but also to improve wider cancer-related outcomes. Herein, we provide a comprehensive review of the intertwined biobehavioral pathways linking depression to cancer progression. In addition, the clinical implications of these findings are critically reviewed. © 2016 Elsevier Ltden
dc.language.isoengen
dc.sourceCancer treatment reviewsen
dc.subjectReviewen
dc.subjectHumanen
dc.subjectNeoplasmsen
dc.subjectHumansen
dc.subjectDisease progressionen
dc.subjectTumor volumeen
dc.subjectCancer prognosisen
dc.subjectTumor microenvironmenten
dc.subjectNeoplasmen
dc.subjectDisease courseen
dc.subjectGenetic polymorphismen
dc.subjectPromoter regionen
dc.subjectProtein expressionen
dc.subjectCancer risken
dc.subjectCancer incidenceen
dc.subjectCarcinogenesisen
dc.subjectDrug useen
dc.subject3 dioxygenaseen
dc.subjectBehavior therapyen
dc.subjectBrain derived neurotrophic factoren
dc.subjectC reactive proteinen
dc.subjectCanceren
dc.subjectCellular immunityen
dc.subjectChronic inflammationen
dc.subjectChronic stressen
dc.subjectDepressive disorderen
dc.subjectDietary intakeen
dc.subjectDisease associationen
dc.subjectDown regulationen
dc.subjectDysbiosisen
dc.subjectGelatinase aen
dc.subjectGelatinase ben
dc.subjectGene expression regulationen
dc.subjectGlucocorticoid receptoren
dc.subjectHpa axisen
dc.subjectImmunoglobulin enhancer binding proteinen
dc.subjectImmunosurveillanceen
dc.subjectIndoleamine 2en
dc.subjectInflammationen
dc.subjectInterleukin 10en
dc.subjectInterleukin 1betaen
dc.subjectInterleukin 2 receptoren
dc.subjectInterleukin 6en
dc.subjectInterleukin 8en
dc.subjectLipid peroxidationen
dc.subjectMajoren
dc.subjectMajor depressionen
dc.subjectMajor depressive disorderen
dc.subjectNitrosative stressen
dc.subjectNonhumanen
dc.subjectOxidative stressen
dc.subjectPathologyen
dc.subjectPhysical activityen
dc.subjectPrevalenceen
dc.subjectPsychiatryen
dc.subjectPsychologyen
dc.subjectReactive oxygen metaboliteen
dc.subjectRecurrent diseaseen
dc.subjectSignal transductionen
dc.subjectSleep disorderen
dc.subjectStressen
dc.subjectT lymphocyteen
dc.subjectTetrahydrobiopterinen
dc.subjectTransforming growth factor betaen
dc.subjectTumor growthen
dc.subjectTumor necrosis factoren
dc.subjectTumor vascularizationen
dc.subjectUpregulationen
dc.subjectVasculotropinen
dc.titleDepression in cancer: The many biobehavioral pathways driving tumor progressionen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.ctrv.2016.11.004
dc.description.volume52
dc.description.startingpage58
dc.description.endingpage70
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidHyphantis, T. [0000-0002-7647-4312]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0002-7647-4312


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