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dc.contributor.authorChauhan, V. P.en
dc.contributor.authorStylianopoulos, T.en
dc.contributor.authorBoucher, Y.en
dc.contributor.authorJain, R. K.en
dc.creatorChauhan, V. P.en
dc.creatorStylianopoulos, T.en
dc.creatorBoucher, Y.en
dc.creatorJain, R. K.en
dc.date.accessioned2019-05-06T12:23:28Z
dc.date.available2019-05-06T12:23:28Z
dc.date.issued2011
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48288
dc.description.abstractTumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport into tumor interstitium from the vascular compartment, and hindered transport through tumor interstitium to the target cells. Four major abnormal physical and physiological properties contribute to these transport barriers. Accumulated solid stress compresses blood vessels to diminish the drug supply to many tumor regions. Immature vasculature with high viscous and geometric resistances and reduced pressure gradients leads to sluggish and heterogeneous blood flow in tumors to further limit drug supply. Nonfunctional lymphatics coupled with highly permeable blood vessels result in elevated hydrostatic pressure in tumors to abrogate convective drug transport from blood vessels into and throughout most of the tumor tissue. Finally, a dense structure of interstitial matrix and cells serves as a tortuous, viscous, and steric barrier to diffusion of therapeutic agents. In this review, we discuss the origins and implications of these barriers. We then highlight strategies for overcoming these barriers by modulating either drug properties or the tumor microenvironment itself to enhance the delivery and effectiveness of drugs in tumors. © Copyright 2011 by Annual Reviews. All rights reserved.en
dc.language.isoengen
dc.sourceAnnual Review of Chemical and Biomolecular Engineeringen
dc.subjectmethodologyen
dc.subjectcanceren
dc.subjecthumanen
dc.subjectNeoplasmsen
dc.subjectHumansen
dc.subjectdrug resistanceen
dc.subjectreviewen
dc.subjectneoplasmen
dc.subjectpathologyen
dc.subjectmetabolismen
dc.subjectpathophysiologyen
dc.subjectAnimalsen
dc.subjectanimalen
dc.subjectBlooden
dc.subjectdrug delivery systemen
dc.subjectDrug Delivery Systemsen
dc.subjectDrug deliveryen
dc.subjectNanostructuresen
dc.subjectTumorsen
dc.subjectmatrixen
dc.subjectSolid stressen
dc.subjectDiseasesen
dc.subjectBiological Transporten
dc.subjectBlood flowen
dc.subjectBlood vesselsen
dc.subjectCancer therapyen
dc.subjectcapillary permeabilityen
dc.subjectDense structuresen
dc.subjectDrug supplyen
dc.subjectDrug transporten
dc.subjectextracellular spaceen
dc.subjectHydrostatic pressureen
dc.subjectmicroenvironmenten
dc.subjectMicroenvironmentsen
dc.subjectNano scaleen
dc.subjectnanomaterialen
dc.subjectnormalizationen
dc.subjectPhysiological propertiesen
dc.subjectPhysiologyen
dc.subjectSteric barrieren
dc.subjectTarget cellsen
dc.subjectTherapeutic agentsen
dc.subjecttransport at the cellular levelen
dc.subjectTransport barrieren
dc.subjectTumor microenvironmenten
dc.subjectTumor tissuesen
dc.subjectVasculatureen
dc.titleDelivery of molecular and nanoscale medicine to tumors: Transport barriers and strategiesen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1146/annurev-chembioeng-061010-114300
dc.description.volume2
dc.description.startingpage281
dc.description.endingpage298
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.description.totalnumpages281-298


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