Superparamagnetic hybrid micelles, based on iron oxide nanoparticles and well-defined diblock copolymers possessing β-ketoester functionalities
Date
2009Source
BiomacromoleculesVolume
10Pages
2662-2671Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
The quality of surface coating of magnetic nanoparticles destined as nanoprobes in clinical applications is of utmost significance for their colloidal stability and biocompatibility. A novel approach for the fabrication of such a coating involves the synthesis of well-defined diblock copolymers based on 2-(acetoacetoxy)ethyl methacrylate (chelating) and poly(ethylene glycol)methyl ether methacrylate (water-soluble, thermoresponsive), prepared by reversible addition-fragmentation chain transfer polymerization. Fabrication of magneto-responsive micelles was accomplished via chemical coprecipitation of Fe(III)/Fe(II) in the presence of diblock copolymers. Further to the characterization of micellar morphologies, optical and thermal properties, assessment of magnetic characteristics disclosed superparamagnetic behavior. The hybrid micelles did not compromise cell viability in cultures, while in vitro uptake by macrophage cells was significantly lower in comparison to that of the clinically applicable contrast agent Resovist, suggesting that these systems can evade rapid uptake by the reticuloendothelial system and be useful agents for in vivo applications. © 2009 American Chemical Society.
Collections
Cite as
Related items
Showing items related by title, author, creator and subject.
-
Article
Fabrication and characterization of superparamagnetic and thermoresponsive hydrogels based on oleic-acid-coated Fe3O4 nanoparticles, hexa(ethylene glycol) methyl ether methacrylate and 2-(acetoacetoxy)ethyl methacrylate
Papaphilippou, P.; Pourgouris, A.; Marinica, O.; Taculescu, A.; Athanasopoulos, G. I.; Vekas, L.; Krasia-Christoforou, T. (2011)Stimuli-responsive hydrogel nanocomposites comprised of swollen polymer networks, in which magnetic nanoparticles are embedded, are a relatively new class of "smart" soft materials presenting a significant impact on various ...
-
Article
Multiresponsive polymer conetworks capable of responding to changes in pH, temperature, and magnetic field: Synthesis, characterization, and evaluation of their ability for controlled uptake and release of solutes
Papaphilippou, P.; Christodoulou, M.; Marinica, O. M.; Taculescu, A.; Vekas, L.; Chrissafis, K.; Krasia-Christoforou, T. (2012)This study deals with the preparation of novel multiresponsive (magnetoresponsive, thermoresponsive and pH-responsive) nanocomposite conetworks consisting of oleic acid-coated magnetite nanoparticles (OA•Fe 3O 4), ...
-
Article
Fabrication and characterization of magnetoresponsive electrospun nanocomposite membranes based on methacrylic random copolymers and magnetite nanoparticles
Savva, I.; Krekos, G.; Taculescu, A.; Marinica, O.; Vekas, L.; Krasia-Christoforou, T. (2012)Magnetoresponsive polymer-based fibrous nanocomposites belonging to the broad category of stimuli-responsive materials, is a relatively new class of soft composite materials, consisting of magnetic nanoparticles embedded ...