dc.contributor.author | Papaphilippou, P. | en |
dc.contributor.author | Loizou, L. | en |
dc.contributor.author | Popa, N. C. | en |
dc.contributor.author | Han, A. | en |
dc.contributor.author | Vekas, L. | en |
dc.contributor.author | Odysseos, A. | en |
dc.contributor.author | Krasia-Christoforou, T. | en |
dc.creator | Papaphilippou, P. | en |
dc.creator | Loizou, L. | en |
dc.creator | Popa, N. C. | en |
dc.creator | Han, A. | en |
dc.creator | Vekas, L. | en |
dc.creator | Odysseos, A. | en |
dc.creator | Krasia-Christoforou, T. | en |
dc.date.accessioned | 2019-05-06T12:24:18Z | |
dc.date.available | 2019-05-06T12:24:18Z | |
dc.date.issued | 2009 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/48700 | |
dc.description.abstract | The quality of surface coating of magnetic nanoparticles destined as nanoprobes in clinical applications is of utmost significance for their colloidal stability and biocompatibility. A novel approach for the fabrication of such a coating involves the synthesis of well-defined diblock copolymers based on 2-(acetoacetoxy)ethyl methacrylate (chelating) and poly(ethylene glycol)methyl ether methacrylate (water-soluble, thermoresponsive), prepared by reversible addition-fragmentation chain transfer polymerization. Fabrication of magneto-responsive micelles was accomplished via chemical coprecipitation of Fe(III)/Fe(II) in the presence of diblock copolymers. Further to the characterization of micellar morphologies, optical and thermal properties, assessment of magnetic characteristics disclosed superparamagnetic behavior. The hybrid micelles did not compromise cell viability in cultures, while in vitro uptake by macrophage cells was significantly lower in comparison to that of the clinically applicable contrast agent Resovist, suggesting that these systems can evade rapid uptake by the reticuloendothelial system and be useful agents for in vivo applications. © 2009 American Chemical Society. | en |
dc.language.iso | eng | en |
dc.source | Biomacromolecules | en |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | priority journal | en |
dc.subject | male | en |
dc.subject | unclassified drug | en |
dc.subject | human cell | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | in vitro study | en |
dc.subject | Polymers | en |
dc.subject | Cell Line | en |
dc.subject | Macrophages | en |
dc.subject | reticuloendothelial system | en |
dc.subject | macrophage | en |
dc.subject | Micelles | en |
dc.subject | Cell membranes | en |
dc.subject | Optical properties | en |
dc.subject | Reversible addition-fragmentation chain transfer polymerization | en |
dc.subject | Superparamagnetic behavior | en |
dc.subject | Ethyl methacrylates | en |
dc.subject | Block copolymers | en |
dc.subject | Esters | en |
dc.subject | magnetism | en |
dc.subject | thermal analysis | en |
dc.subject | Ferric Compounds | en |
dc.subject | nanoparticle | en |
dc.subject | optics | en |
dc.subject | Ketoester | en |
dc.subject | Copolymerization | en |
dc.subject | Polymer blends | en |
dc.subject | Nanoparticles | en |
dc.subject | Diblock copolymer | en |
dc.subject | Superparamagnetism | en |
dc.subject | Cell culture | en |
dc.subject | Ethylene | en |
dc.subject | copolymer | en |
dc.subject | water | en |
dc.subject | 2 (acetoacetoxy)ethyl methacrylate | en |
dc.subject | polymerization | en |
dc.subject | precipitation | en |
dc.subject | Ethers | en |
dc.subject | Ethylene glycol | en |
dc.subject | Magnetic characteristic | en |
dc.subject | Magnetics | en |
dc.subject | Thermo-responsive | en |
dc.subject | beta oxocarboxylic acid ester | en |
dc.subject | Biocompatibility | en |
dc.subject | Cell Survival | en |
dc.subject | Cell viability | en |
dc.subject | chelating agent | en |
dc.subject | Chemical co-precipitation | en |
dc.subject | Clinical application | en |
dc.subject | Colloidal Stability | en |
dc.subject | Contrast agent | en |
dc.subject | Coprecipitation | en |
dc.subject | ester derivative | en |
dc.subject | ferucarbotran | en |
dc.subject | fragmentation reaction | en |
dc.subject | hybrid | en |
dc.subject | Hybrid micelle | en |
dc.subject | In-vitro | en |
dc.subject | In-vivo | en |
dc.subject | iron oxide | en |
dc.subject | Iron oxide nanoparticle | en |
dc.subject | Iron oxides | en |
dc.subject | Macrophage cells | en |
dc.subject | Magnetic nanoparticles | en |
dc.subject | methacrylic acid | en |
dc.subject | micelle | en |
dc.subject | Optical and thermal properties | en |
dc.subject | Plastic coatings | en |
dc.subject | Poly(ethylene glycol) methyl ether methacrylate (PEG-MMA) | en |
dc.subject | poly(ethylene glycol)methyl ether methacrylate | en |
dc.subject | Polyethylene glycols | en |
dc.subject | Polyethylene oxides | en |
dc.subject | Reticuloendothelial systems | en |
dc.subject | Superparamagnetics | en |
dc.subject | Surface coatings | en |
dc.subject | Thermodynamic properties | en |
dc.title | Superparamagnetic hybrid micelles, based on iron oxide nanoparticles and well-defined diblock copolymers possessing β-ketoester functionalities | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1021/bm9005936 | |
dc.description.volume | 10 | |
dc.description.startingpage | 2662 | |
dc.description.endingpage | 2671 | |
dc.author.faculty | Πολυτεχνική Σχολή / Faculty of Engineering | |
dc.author.department | Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Krasia-Christoforou, T. [0000-0002-9915-491X] | |
dc.description.totalnumpages | 2662-2671 | |
dc.gnosis.orcid | 0000-0002-9915-491X | |