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dc.contributor.authorPapaphilippou, P.en
dc.contributor.authorLoizou, L.en
dc.contributor.authorPopa, N. C.en
dc.contributor.authorHan, A.en
dc.contributor.authorVekas, L.en
dc.contributor.authorOdysseos, A.en
dc.contributor.authorKrasia-Christoforou, T.en
dc.creatorPapaphilippou, P.en
dc.creatorLoizou, L.en
dc.creatorPopa, N. C.en
dc.creatorHan, A.en
dc.creatorVekas, L.en
dc.creatorOdysseos, A.en
dc.creatorKrasia-Christoforou, T.en
dc.date.accessioned2019-05-06T12:24:18Z
dc.date.available2019-05-06T12:24:18Z
dc.date.issued2009
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48700
dc.description.abstractThe quality of surface coating of magnetic nanoparticles destined as nanoprobes in clinical applications is of utmost significance for their colloidal stability and biocompatibility. A novel approach for the fabrication of such a coating involves the synthesis of well-defined diblock copolymers based on 2-(acetoacetoxy)ethyl methacrylate (chelating) and poly(ethylene glycol)methyl ether methacrylate (water-soluble, thermoresponsive), prepared by reversible addition-fragmentation chain transfer polymerization. Fabrication of magneto-responsive micelles was accomplished via chemical coprecipitation of Fe(III)/Fe(II) in the presence of diblock copolymers. Further to the characterization of micellar morphologies, optical and thermal properties, assessment of magnetic characteristics disclosed superparamagnetic behavior. The hybrid micelles did not compromise cell viability in cultures, while in vitro uptake by macrophage cells was significantly lower in comparison to that of the clinically applicable contrast agent Resovist, suggesting that these systems can evade rapid uptake by the reticuloendothelial system and be useful agents for in vivo applications. © 2009 American Chemical Society.en
dc.language.isoengen
dc.sourceBiomacromoleculesen
dc.subjectarticleen
dc.subjecthumanen
dc.subjectpriority journalen
dc.subjectmaleen
dc.subjectunclassified drugen
dc.subjecthuman cellen
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectin vitro studyen
dc.subjectPolymersen
dc.subjectCell Lineen
dc.subjectMacrophagesen
dc.subjectreticuloendothelial systemen
dc.subjectmacrophageen
dc.subjectMicellesen
dc.subjectCell membranesen
dc.subjectOptical propertiesen
dc.subjectReversible addition-fragmentation chain transfer polymerizationen
dc.subjectSuperparamagnetic behavioren
dc.subjectEthyl methacrylatesen
dc.subjectBlock copolymersen
dc.subjectEstersen
dc.subjectmagnetismen
dc.subjectthermal analysisen
dc.subjectFerric Compoundsen
dc.subjectnanoparticleen
dc.subjectopticsen
dc.subjectKetoesteren
dc.subjectCopolymerizationen
dc.subjectPolymer blendsen
dc.subjectNanoparticlesen
dc.subjectDiblock copolymeren
dc.subjectSuperparamagnetismen
dc.subjectCell cultureen
dc.subjectEthyleneen
dc.subjectcopolymeren
dc.subjectwateren
dc.subject2 (acetoacetoxy)ethyl methacrylateen
dc.subjectpolymerizationen
dc.subjectprecipitationen
dc.subjectEthersen
dc.subjectEthylene glycolen
dc.subjectMagnetic characteristicen
dc.subjectMagneticsen
dc.subjectThermo-responsiveen
dc.subjectbeta oxocarboxylic acid esteren
dc.subjectBiocompatibilityen
dc.subjectCell Survivalen
dc.subjectCell viabilityen
dc.subjectchelating agenten
dc.subjectChemical co-precipitationen
dc.subjectClinical applicationen
dc.subjectColloidal Stabilityen
dc.subjectContrast agenten
dc.subjectCoprecipitationen
dc.subjectester derivativeen
dc.subjectferucarbotranen
dc.subjectfragmentation reactionen
dc.subjecthybriden
dc.subjectHybrid micelleen
dc.subjectIn-vitroen
dc.subjectIn-vivoen
dc.subjectiron oxideen
dc.subjectIron oxide nanoparticleen
dc.subjectIron oxidesen
dc.subjectMacrophage cellsen
dc.subjectMagnetic nanoparticlesen
dc.subjectmethacrylic aciden
dc.subjectmicelleen
dc.subjectOptical and thermal propertiesen
dc.subjectPlastic coatingsen
dc.subjectPoly(ethylene glycol) methyl ether methacrylate (PEG-MMA)en
dc.subjectpoly(ethylene glycol)methyl ether methacrylateen
dc.subjectPolyethylene glycolsen
dc.subjectPolyethylene oxidesen
dc.subjectReticuloendothelial systemsen
dc.subjectSuperparamagneticsen
dc.subjectSurface coatingsen
dc.subjectThermodynamic propertiesen
dc.titleSuperparamagnetic hybrid micelles, based on iron oxide nanoparticles and well-defined diblock copolymers possessing β-ketoester functionalitiesen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1021/bm9005936
dc.description.volume10
dc.description.startingpage2662
dc.description.endingpage2671
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidKrasia-Christoforou, T. [0000-0002-9915-491X]
dc.description.totalnumpages2662-2671
dc.gnosis.orcid0000-0002-9915-491X


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