dc.contributor.author | Jabbar, S. | en |
dc.contributor.author | Strati, Katerina | en |
dc.contributor.author | Shin, M. K. | en |
dc.contributor.author | Pitot, H. C. | en |
dc.contributor.author | Lambert, P. F. | en |
dc.creator | Jabbar, S. | en |
dc.creator | Strati, Katerina | en |
dc.creator | Shin, M. K. | en |
dc.creator | Pitot, H. C. | en |
dc.creator | Lambert, P. F. | en |
dc.date.accessioned | 2019-11-04T12:50:45Z | |
dc.date.available | 2019-11-04T12:50:45Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53141 | |
dc.description.abstract | High-risk human papillomaviruses (HPVs) contribute to cervical and other anogenital cancers, and they are also linked etiologically to a subset of head and neck squamous cell carcinomas (HNSCC). We previously established a model for HPV-associated HNSCC in which we treated transgenic mice expressing the papillomaviral oncoproteins with the chemical carcinogen 4-nitroquinoline-1-oxide (4-NQO). We found that the HPV-16 E7 oncoprotein was highly potent in causing HNSCC, and its dominance masked any potential oncogenic contribution of E6, a second papillomaviral oncoprotein commonly expressed in human cancers. In the current study, we shortened the duration of treatment with 4-NQO to reduce the incidence of cancers and discovered a striking synergy between E6 and E7 in causing HNSCC. Comparing the oncogenic properties of wild-type versus mutant E6 genes in this model for HNSCC uncovered a role for some but not other cellular targets of E6 previously shown to contribute to cervical cancer. © 2010 Elsevier Inc. | en |
dc.source | Virology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956914783&doi=10.1016%2fj.virol.2010.08.003&partnerID=40&md5=211e13ef816ec8cbb07efafc608cee45 | |
dc.subject | article | en |
dc.subject | controlled study | en |
dc.subject | priority journal | en |
dc.subject | head and neck tumor | en |
dc.subject | protein expression | en |
dc.subject | complication | en |
dc.subject | cancer incidence | en |
dc.subject | disease association | en |
dc.subject | nonhuman | en |
dc.subject | oncoprotein | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | animal tissue | en |
dc.subject | disease model | en |
dc.subject | mouse | en |
dc.subject | physiology | en |
dc.subject | head and neck cancer | en |
dc.subject | Head and Neck Neoplasms | en |
dc.subject | pathogenicity | en |
dc.subject | virology | en |
dc.subject | protein function | en |
dc.subject | wild type | en |
dc.subject | carcinogen | en |
dc.subject | alpha helix | en |
dc.subject | Mus | en |
dc.subject | virulence factor | en |
dc.subject | Virulence Factors | en |
dc.subject | protein protein interaction | en |
dc.subject | repressor protein | en |
dc.subject | Repressor Proteins | en |
dc.subject | Disease Models, Animal | en |
dc.subject | mutant protein | en |
dc.subject | chemical carcinogenesis | en |
dc.subject | Mus musculus | en |
dc.subject | Carcinogens | en |
dc.subject | binding site | en |
dc.subject | Mice, Transgenic | en |
dc.subject | transgenic mouse | en |
dc.subject | Human papillomavirus type 16 | en |
dc.subject | 4 nitroquinoline 1 oxide | en |
dc.subject | 4-Nitroquinoline-1-oxide | en |
dc.subject | chemically induced | en |
dc.subject | E6 oncoprotein | en |
dc.subject | E6 protein, Human papillomavirus type 16 | en |
dc.subject | E7 oncoprotein | en |
dc.subject | Head and neck squamous cell carcinoma | en |
dc.subject | High-risk human papillomaviruses | en |
dc.subject | Human papillomavirus | en |
dc.subject | Human papillomavirus 16 | en |
dc.subject | oncogene protein E7, Human papillomavirus type 16 | en |
dc.subject | Oncogene Proteins, Viral | en |
dc.subject | Papillomaviridae | en |
dc.subject | Papillomavirus E7 Proteins | en |
dc.subject | papillomavirus infection | en |
dc.subject | Papillomavirus Infections | en |
dc.subject | PDZ protein | en |
dc.subject | protein E6 | en |
dc.subject | protein E7 | en |
dc.subject | virus carcinogenesis | en |
dc.title | Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.virol.2010.08.003 | |
dc.description.volume | 407 | |
dc.description.startingpage | 60 | |
dc.description.endingpage | 67 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :28</p> | en |
dc.source.abbreviation | Virology | en |
dc.contributor.orcid | Strati, Katerina [0000-0002-2332-787X] | |
dc.gnosis.orcid | 0000-0002-2332-787X | |