A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes
dc.contributor.author | Kesarwani, M. | en |
dc.contributor.author | Hazan, R. | en |
dc.contributor.author | He, J. | en |
dc.contributor.author | Que, Y. | en |
dc.contributor.author | Apidianakis, Yiorgos | en |
dc.contributor.author | Lesic, B. | en |
dc.contributor.author | Xiao, G. | en |
dc.contributor.author | Dekimpe, V. | en |
dc.contributor.author | Milot, S. | en |
dc.contributor.author | Déziel, Eric | en |
dc.contributor.author | Lépine, F. | en |
dc.contributor.author | Rahme, L. G. | en |
dc.creator | Kesarwani, M. | en |
dc.creator | Hazan, R. | en |
dc.creator | He, J. | en |
dc.creator | Que, Y. | en |
dc.creator | Apidianakis, Yiorgos | en |
dc.creator | Lesic, B. | en |
dc.creator | Xiao, G. | en |
dc.creator | Dekimpe, V. | en |
dc.creator | Milot, S. | en |
dc.creator | Déziel, Eric | en |
dc.creator | Lépine, F. | en |
dc.creator | Rahme, L. G. | en |
dc.date.accessioned | 2019-11-04T12:51:49Z | |
dc.date.available | 2019-11-04T12:51:49Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1553-7366 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53167 | |
dc.description.abstract | A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial phenotypes controlled by complex regulatory networks that sense and respond to the host environment. Although bacterial signals that contribute to a successful acute infection have been identified in a number of pathogens, the signals that mediate the onset and establishment of chronic infections have yet to be discovered. We identified a volatile, low molecular weight molecule, 2-amino acetophenone (2-AA), produced by the opportunistic human pathogen Pseudomonas aeruginosa that reduces bacterial virulence in vivo in flies and in an acute mouse infection model. 2-AA modulates the activity of the virulence regulator MvfR (multiple virulence factor regulator) via a negative feedback loop and it promotes the emergence of P. aeruginosa phenotypes that likely promote chronic lung infections, including accumulation of lasR mutants, long-term survival at stationary phase, and persistence in a Drosophila infection model. We report for the first time the existence of a quorum sensing (QS) regulated volatile molecule that induces bistability phenotype by stochastically silencing acute virulence functions in P. aeruginosa. We propose that 2-AA mediates changes in a subpopulation of cells that facilitate the exploitation of dynamic host environments and promote gene expression changes that favor chronic infections. © 2011 Kesarwani et al. | en |
dc.source | PLoS Pathogens | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052314915&doi=10.1371%2fjournal.ppat.1002192&partnerID=40&md5=c0f48445335b7a7ee68f17bb13b7783a | |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | survival | en |
dc.subject | unclassified drug | en |
dc.subject | down regulation | en |
dc.subject | gene expression regulation | en |
dc.subject | nonhuman | en |
dc.subject | metabolism | en |
dc.subject | phenotype | en |
dc.subject | gene expression | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | disease model | en |
dc.subject | mouse | en |
dc.subject | genetics | en |
dc.subject | physiology | en |
dc.subject | pathogenicity | en |
dc.subject | chronic disease | en |
dc.subject | lung infection | en |
dc.subject | Pseudomonas aeruginosa | en |
dc.subject | Pseudomonas Infections | en |
dc.subject | molecular weight | en |
dc.subject | regulatory mechanism | en |
dc.subject | mutation | en |
dc.subject | bacterial pneumonia | en |
dc.subject | gene locus | en |
dc.subject | drug synthesis | en |
dc.subject | molecule | en |
dc.subject | in vivo study | en |
dc.subject | Bacteria (microorganisms) | en |
dc.subject | bacterial protein | en |
dc.subject | Bacterial Proteins | en |
dc.subject | bacterial virulence | en |
dc.subject | Drosophila melanogaster | en |
dc.subject | Gene Expression Regulation, Bacterial | en |
dc.subject | virulence factor | en |
dc.subject | Pseudomonas infection | en |
dc.subject | Drosophila | en |
dc.subject | Disease Models, Animal | en |
dc.subject | quorum sensing | en |
dc.subject | regulon | en |
dc.subject | 2 aminoacetophenone | en |
dc.subject | 2-aminoacetophenone | en |
dc.subject | acetophenone derivative | en |
dc.subject | Acetophenones | en |
dc.subject | acute disease | en |
dc.subject | antimicrobial activity | en |
dc.subject | bacterial survival | en |
dc.subject | LasR protein, Pseudomonas aeruginosa | en |
dc.subject | multiple virulence factor regulator | en |
dc.subject | negative feedback | en |
dc.subject | Pneumonia, Bacterial | en |
dc.subject | Trans-Activators | en |
dc.subject | transactivator protein | en |
dc.title | A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1371/journal.ppat.1002192 | |
dc.description.volume | 7 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :40</p> | en |
dc.source.abbreviation | PLoS Pathog. | en |
dc.contributor.orcid | Apidianakis, Yiorgos [0000-0002-7465-3560] | |
dc.gnosis.orcid | 0000-0002-7465-3560 |
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