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dc.contributor.authorKesarwani, M.en
dc.contributor.authorHazan, R.en
dc.contributor.authorHe, J.en
dc.contributor.authorQue, Y.en
dc.contributor.authorApidianakis, Yiorgosen
dc.contributor.authorLesic, B.en
dc.contributor.authorXiao, G.en
dc.contributor.authorDekimpe, V.en
dc.contributor.authorMilot, S.en
dc.contributor.authorDéziel, Ericen
dc.contributor.authorLépine, F.en
dc.contributor.authorRahme, L. G.en
dc.creatorKesarwani, M.en
dc.creatorHazan, R.en
dc.creatorHe, J.en
dc.creatorQue, Y.en
dc.creatorApidianakis, Yiorgosen
dc.creatorLesic, B.en
dc.creatorXiao, G.en
dc.creatorDekimpe, V.en
dc.creatorMilot, S.en
dc.creatorDéziel, Ericen
dc.creatorLépine, F.en
dc.creatorRahme, L. G.en
dc.date.accessioned2019-11-04T12:51:49Z
dc.date.available2019-11-04T12:51:49Z
dc.date.issued2011
dc.identifier.issn1553-7366
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53167
dc.description.abstractA significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial phenotypes controlled by complex regulatory networks that sense and respond to the host environment. Although bacterial signals that contribute to a successful acute infection have been identified in a number of pathogens, the signals that mediate the onset and establishment of chronic infections have yet to be discovered. We identified a volatile, low molecular weight molecule, 2-amino acetophenone (2-AA), produced by the opportunistic human pathogen Pseudomonas aeruginosa that reduces bacterial virulence in vivo in flies and in an acute mouse infection model. 2-AA modulates the activity of the virulence regulator MvfR (multiple virulence factor regulator) via a negative feedback loop and it promotes the emergence of P. aeruginosa phenotypes that likely promote chronic lung infections, including accumulation of lasR mutants, long-term survival at stationary phase, and persistence in a Drosophila infection model. We report for the first time the existence of a quorum sensing (QS) regulated volatile molecule that induces bistability phenotype by stochastically silencing acute virulence functions in P. aeruginosa. We propose that 2-AA mediates changes in a subpopulation of cells that facilitate the exploitation of dynamic host environments and promote gene expression changes that favor chronic infections. © 2011 Kesarwani et al.en
dc.sourcePLoS Pathogensen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-80052314915&doi=10.1371%2fjournal.ppat.1002192&partnerID=40&md5=c0f48445335b7a7ee68f17bb13b7783a
dc.subjectarticleen
dc.subjecthumanen
dc.subjectHumansen
dc.subjectcontrolled studyen
dc.subjectfemaleen
dc.subjectsurvivalen
dc.subjectunclassified drugen
dc.subjectdown regulationen
dc.subjectgene expression regulationen
dc.subjectnonhumanen
dc.subjectmetabolismen
dc.subjectphenotypeen
dc.subjectgene expressionen
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectanimalen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectdisease modelen
dc.subjectmouseen
dc.subjectgeneticsen
dc.subjectphysiologyen
dc.subjectpathogenicityen
dc.subjectchronic diseaseen
dc.subjectlung infectionen
dc.subjectPseudomonas aeruginosaen
dc.subjectPseudomonas Infectionsen
dc.subjectmolecular weighten
dc.subjectregulatory mechanismen
dc.subjectmutationen
dc.subjectbacterial pneumoniaen
dc.subjectgene locusen
dc.subjectdrug synthesisen
dc.subjectmoleculeen
dc.subjectin vivo studyen
dc.subjectBacteria (microorganisms)en
dc.subjectbacterial proteinen
dc.subjectBacterial Proteinsen
dc.subjectbacterial virulenceen
dc.subjectDrosophila melanogasteren
dc.subjectGene Expression Regulation, Bacterialen
dc.subjectvirulence factoren
dc.subjectPseudomonas infectionen
dc.subjectDrosophilaen
dc.subjectDisease Models, Animalen
dc.subjectquorum sensingen
dc.subjectregulonen
dc.subject2 aminoacetophenoneen
dc.subject2-aminoacetophenoneen
dc.subjectacetophenone derivativeen
dc.subjectAcetophenonesen
dc.subjectacute diseaseen
dc.subjectantimicrobial activityen
dc.subjectbacterial survivalen
dc.subjectLasR protein, Pseudomonas aeruginosaen
dc.subjectmultiple virulence factor regulatoren
dc.subjectnegative feedbacken
dc.subjectPneumonia, Bacterialen
dc.subjectTrans-Activatorsen
dc.subjecttransactivator proteinen
dc.titleA quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypesen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1371/journal.ppat.1002192
dc.description.volume7
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :40</p>en
dc.source.abbreviationPLoS Pathog.en
dc.contributor.orcidApidianakis, Yiorgos [0000-0002-7465-3560]
dc.gnosis.orcid0000-0002-7465-3560


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