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dc.contributor.authorPolydorou, Christianaen
dc.contributor.authorGeorgiades, Pantelisen
dc.creatorPolydorou, Christianaen
dc.creatorGeorgiades, Pantelisen
dc.date.accessioned2019-11-04T12:52:32Z
dc.date.available2019-11-04T12:52:32Z
dc.date.issued2013
dc.identifier.issn2041-1723
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53324
dc.description.abstractAlthough extraembryonic ectoderm trophoblast signals the embryo for primitive streak initiation, a prerequisite for gastrulation, it is unknown whether it also signals for the progression of gastrulation after primitive streak initiation. Here, using Ets2-/- mice, we show that trophoblast signalling is also required in vivo for primitive streak elongation, completion of intraembryonic mesoderm epithelial-mesenchymal transition and the development of anterior primitive streak derivatives such as the node. We show that Ets2-dependent trophoblast signalling is required for the maintenance of high levels of Nodal and Wnt3 expression in the epiblast and for the induction of Snail expression in the primitive streak, between embryonic day 6.3 and 6.7. Within extraembryonic ectoderm trophoblast, Ets2 maintains the expression of the transcription factors Elf5, Cdx2 and Eomes, and that of the signalling molecule Bmp4. We propose a model that provides a genetic explanation as to how Ets2 in trophoblast mediates the progression of gastrulation within the epiblast. © 2013 Macmillan Publishers Limited. All rights reserved.en
dc.sourceNature Communicationsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84877760834&doi=10.1038%2fncomms2646&partnerID=40&md5=68621a490ef90748995343fdd023ecae
dc.subjectarticleen
dc.subjectprotein expressionen
dc.subjectnonhumanen
dc.subjectgene expressionen
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectmouseen
dc.subjectSignal Transductionen
dc.subjectgenetic analysisen
dc.subjecttranscription factor Snailen
dc.subjectepithelial mesenchymal transitionen
dc.subjectin vivo studyen
dc.subjectembryoen
dc.subjectPhenotypeen
dc.subjectGene Expression Regulation, Developmentalen
dc.subjectGenes, Regulatoren
dc.subjectMice, Knockouten
dc.subjectectodermen
dc.subjectmesodermen
dc.subjectgenetic variationen
dc.subjecttrophoblasten
dc.subjectTrophoblastsen
dc.subjectprimitive streaken
dc.subjectProto-Oncogene Protein c-ets-2en
dc.subjecttranscription factor Ets 2en
dc.subjectbone morphogenetic protein 4en
dc.subjectrodenten
dc.subjecttranscription factor Cdx2en
dc.subjectgastrulationen
dc.subjectprotein Nodalen
dc.subjectsignalingen
dc.subjectsnailen
dc.subjectWnt3 proteinen
dc.titleEts2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiationen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/ncomms2646
dc.description.volume4
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :13</p>en
dc.source.abbreviationNat.Commun.en
dc.contributor.orcidGeorgiades, Pantelis [0000-0002-5538-3163]
dc.gnosis.orcid0000-0002-5538-3163


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