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dc.contributor.authorTonetti, D. A.en
dc.contributor.authorZhang, Y.en
dc.contributor.authorZhao, H.en
dc.contributor.authorLim, S. -Ben
dc.contributor.authorConstantinou, Andreas I.en
dc.creatorTonetti, D. A.en
dc.creatorZhang, Y.en
dc.creatorZhao, H.en
dc.creatorLim, S. -Ben
dc.creatorConstantinou, Andreas I.en
dc.date.accessioned2019-11-04T12:52:46Z
dc.date.available2019-11-04T12:52:46Z
dc.date.issued2007
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53417
dc.description.abstractSoy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen (TAM) for prevention or treatment of breast cancer. We previously described a T47D:A18/protein kinase C (PKC)α TAM-resistant tumor model that exhibits autonomous growth and estradiol-induced tumor regression. We compared the estrogenicity of the isoflavones genistein, daidzein, and the daidzein metabolite equol in the parental T47D:A18 and T47D:A18/PKCα cell lines in vitro and in vivo. Whereas equol exerts estrogenic effects on T47D:A18 cells in vitro, none of the isoflavones stimulated T47D:A18 tumor growth. T47D:A18/PKCα tumor growth was partially stimulated by genistein, yet partially inhibited by daidzein. Interestingly, coadministration of TAM with either daidzein or genistein produced tumors of greater size than with TAM alone. These findings suggest that simultaneous consumption of isoflavone supplements with TAM may not be safe. Copyright © 2007, Lawrence Erlbaum Associates, Inc.en
dc.sourceNutrition and canceren
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34548204360&partnerID=40&md5=0d13b25af787be43440861db3eb5685b
dc.subjectarticleen
dc.subjectFemaleen
dc.subjectAntineoplastic Agentsen
dc.subjecthumanen
dc.subjecttamoxifenen
dc.subjectHumansen
dc.subjectbreast canceren
dc.subjectBreast Neoplasmsen
dc.subjectcontrolled studyen
dc.subjectdrug effecten
dc.subjectdrug resistanceen
dc.subjectSafetyen
dc.subjectCell Divisionen
dc.subjectcell proliferationen
dc.subjectnonhumanen
dc.subjectDrug Interactionsen
dc.subjecttumor regressionen
dc.subjecthuman cellen
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectmouseen
dc.subjectRandom Allocationen
dc.subjectdaidzeinen
dc.subjectgenisteinen
dc.subjectestradiolen
dc.subjectisoflavone derivativeen
dc.subjectIsoflavonesen
dc.subjectAntineoplastic Agents, Hormonalen
dc.subjectCell Line, Tumoren
dc.subjectMice, Nudeen
dc.subjectSoybeansen
dc.subjectfood compositionen
dc.subjectphytoestrogenen
dc.subjectequolen
dc.subjectprotein kinase C alphaen
dc.titleThe effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKCαen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume58
dc.description.startingpage222
dc.description.endingpage229
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :24</p>en
dc.source.abbreviationNutr.Canceren
dc.contributor.orcidConstantinou, Andreas I. [0000-0003-0365-1821]
dc.gnosis.orcid0000-0003-0365-1821


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