dc.contributor.author | Tonetti, D. A. | en |
dc.contributor.author | Zhang, Y. | en |
dc.contributor.author | Zhao, H. | en |
dc.contributor.author | Lim, S. -B | en |
dc.contributor.author | Constantinou, Andreas I. | en |
dc.creator | Tonetti, D. A. | en |
dc.creator | Zhang, Y. | en |
dc.creator | Zhao, H. | en |
dc.creator | Lim, S. -B | en |
dc.creator | Constantinou, Andreas I. | en |
dc.date.accessioned | 2019-11-04T12:52:46Z | |
dc.date.available | 2019-11-04T12:52:46Z | |
dc.date.issued | 2007 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53417 | |
dc.description.abstract | Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen (TAM) for prevention or treatment of breast cancer. We previously described a T47D:A18/protein kinase C (PKC)α TAM-resistant tumor model that exhibits autonomous growth and estradiol-induced tumor regression. We compared the estrogenicity of the isoflavones genistein, daidzein, and the daidzein metabolite equol in the parental T47D:A18 and T47D:A18/PKCα cell lines in vitro and in vivo. Whereas equol exerts estrogenic effects on T47D:A18 cells in vitro, none of the isoflavones stimulated T47D:A18 tumor growth. T47D:A18/PKCα tumor growth was partially stimulated by genistein, yet partially inhibited by daidzein. Interestingly, coadministration of TAM with either daidzein or genistein produced tumors of greater size than with TAM alone. These findings suggest that simultaneous consumption of isoflavone supplements with TAM may not be safe. Copyright © 2007, Lawrence Erlbaum Associates, Inc. | en |
dc.source | Nutrition and cancer | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34548204360&partnerID=40&md5=0d13b25af787be43440861db3eb5685b | |
dc.subject | article | en |
dc.subject | Female | en |
dc.subject | Antineoplastic Agents | en |
dc.subject | human | en |
dc.subject | tamoxifen | en |
dc.subject | Humans | en |
dc.subject | breast cancer | en |
dc.subject | Breast Neoplasms | en |
dc.subject | controlled study | en |
dc.subject | drug effect | en |
dc.subject | drug resistance | en |
dc.subject | Safety | en |
dc.subject | Cell Division | en |
dc.subject | cell proliferation | en |
dc.subject | nonhuman | en |
dc.subject | Drug Interactions | en |
dc.subject | tumor regression | en |
dc.subject | human cell | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | mouse | en |
dc.subject | Random Allocation | en |
dc.subject | daidzein | en |
dc.subject | genistein | en |
dc.subject | estradiol | en |
dc.subject | isoflavone derivative | en |
dc.subject | Isoflavones | en |
dc.subject | Antineoplastic Agents, Hormonal | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Mice, Nude | en |
dc.subject | Soybeans | en |
dc.subject | food composition | en |
dc.subject | phytoestrogen | en |
dc.subject | equol | en |
dc.subject | protein kinase C alpha | en |
dc.title | The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKCα | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 58 | |
dc.description.startingpage | 222 | |
dc.description.endingpage | 229 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :24</p> | en |
dc.source.abbreviation | Nutr.Cancer | en |
dc.contributor.orcid | Constantinou, Andreas I. [0000-0003-0365-1821] | |
dc.gnosis.orcid | 0000-0003-0365-1821 | |