Tissue communication in regenerative inflammatory signaling: Lessons from the fly gut
dc.contributor.author | Kux, K. | en |
dc.contributor.author | Pitsouli, Chrysoula | en |
dc.creator | Kux, K. | en |
dc.creator | Pitsouli, Chrysoula | en |
dc.date.accessioned | 2019-11-04T12:52:16Z | |
dc.date.available | 2019-11-04T12:52:16Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2235-2988 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53215 | |
dc.description.abstract | The intestine, as a barrier epithelium, serves in the first line of defense against invading pathogens and damaging agents that enter the body via food ingestion. Maintenance of intestinal homeostasis is therefore key to organismal health. To maintain homeostasis, intestinal stem cells (ISCs) continuously replace lost or damaged intestinal epithelial cells in organisms ranging from Drosophila to humans. Interestingly, intestinal damage upon ingestion of chemicals or pathogenic bacteria leads to an inflammatory response in the Drosophila intestine, which promotes regeneration and predisposes to tumorigenesis. This regenerative inflammatory signaling culminates in proliferation and differentiation of ISCs that replenish the damaged intestinal cells and is regulated by the interplay of conserved cell-cell communication pathways, such as the JNK, JAK/STAT, Wnt/Wingless, Notch, InR, PVR, EGFR, and Hippo. These pathways are induced by signals emanating not only from the damaged intestinal epithelial cells, but also from neighboring tissues associated with the intestinal epithelium, such as the muscles and the trachea, or distant tissues, such as the wounded epidermis and the brain. Here we review tissue communication during homeostasis and regenerative inflammatory signaling in Drosophila focusing on the signals that emanate from non-intestinal epithelial tissues to ensure intestinal integrity. © 2014 Kux and Pitsouli. | en |
dc.source | Frontiers in Cellular and Infection Microbiology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906995156&doi=10.3389%2ffcimb.2014.00049&partnerID=40&md5=dae13e7cfcefb3badd45e7e61d6f0595 | |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | cell proliferation | en |
dc.subject | carcinogenesis | en |
dc.subject | nonhuman | en |
dc.subject | oxidative stress | en |
dc.subject | pathology | en |
dc.subject | signal transduction | en |
dc.subject | epidermal growth factor receptor | en |
dc.subject | metabolism | en |
dc.subject | Animals | en |
dc.subject | inflammation | en |
dc.subject | animal | en |
dc.subject | microbiology | en |
dc.subject | insulin | en |
dc.subject | aging | en |
dc.subject | physiology | en |
dc.subject | gastrointestinal tract | en |
dc.subject | cell differentiation | en |
dc.subject | Janus kinase | en |
dc.subject | Short Survey | en |
dc.subject | Stem cells | en |
dc.subject | Homeostasis | en |
dc.subject | Drosophila melanogaster | en |
dc.subject | intestine flora | en |
dc.subject | Drosophila | en |
dc.subject | intestine infection | en |
dc.subject | epidermis | en |
dc.subject | Muscle, Smooth | en |
dc.subject | regeneration | en |
dc.subject | colon polyposis | en |
dc.subject | injuries | en |
dc.subject | intestinal stem cell | en |
dc.subject | Intestine | en |
dc.subject | intestine injury | en |
dc.subject | metamorphosis | en |
dc.subject | Pectobacterium carotovorum | en |
dc.subject | Regenerative inflammatory signaling | en |
dc.subject | Signaling pathways | en |
dc.subject | smooth muscle | en |
dc.subject | STAT protein | en |
dc.subject | Tissue communication | en |
dc.subject | vasculotropin receptor | en |
dc.subject | Wnt1 protein | en |
dc.subject | wound healing | en |
dc.title | Tissue communication in regenerative inflammatory signaling: Lessons from the fly gut | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.3389/fcimb.2014.00049 | |
dc.description.volume | 4 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :12</p> | en |
dc.source.abbreviation | Front.Cell.Infect.Microbiol. | en |
dc.contributor.orcid | Pitsouli, Chrysoula [0000-0003-4074-9684] | |
dc.gnosis.orcid | 0000-0003-4074-9684 |
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