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dc.contributor.authorKossivas, Fotisen
dc.contributor.authorAngeli, Stelios I.en
dc.contributor.authorKafouris, Demetrisen
dc.contributor.authorPatrickios, Costas S.en
dc.contributor.authorTzagarakis, V.en
dc.contributor.authorConstantinides, Christakisen
dc.creatorKossivas, Fotisen
dc.creatorAngeli, Stelios I.en
dc.creatorKafouris, Demetrisen
dc.creatorPatrickios, Costas S.en
dc.creatorTzagarakis, V.en
dc.creatorConstantinides, Christakisen
dc.date.accessioned2019-11-21T06:20:04Z
dc.date.available2019-11-21T06:20:04Z
dc.date.issued2012
dc.identifier.issn1748-6041
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55706
dc.description.abstractThis study uses standard synthetic methodologies to produce tissue-mimicking materials that match the morphology and emulate the in vivo murine and human cardiac mechanical and imaging characteristics, with dynamic mechanical analysis, atomic force microscopy (AFM), scanning electron microscopy (SEM) and magnetic resonance imaging. In accordance with such aims, poly(glycerol sebacate) (PGS) elastomeric materials were synthesized (at two different glycerol (G)-sebacic (S) acid molar ratiosen
dc.description.abstractthe first was synthesized using a G:S molar ratio of 2:2, while the second from a 2:5 G:S molar ratio, resulting in PGS2:2 and PGS2:5 elastomers, respectively). Unlike the synthesized PGS2:2 elastomers, the PGS2:5 materials were characterized by an overall mechanical instability in their loading behavior under the three successive loading conditions tested. An oscillatory response in the mechanical properties of the synthesized elastomers was observed throughout the loading cycles, with measured increased storage modulus values at the first loading cycle, stabilizing to lower values at subsequent cycles. These elastomers were characterized at 4°C and were found to have storage modulus values of 850 and 1430 kPa at the third loading cycle, respectively, in agreement with previously reported values of the rat and human myocardium. SEM of surface topology indicated minor degradation of synthesized materials at 10 and 20 d post-immersion in the PBS buffer solution, with a noted cluster formation on the PGS2:5 elastomers. AFM nanoindentation experiments were also conducted for the measurement of the Young modulus of the sample surface (no bulk contribution). Correspondingly, the PGS2:2 elastomer indicated significantly decreased surface Young's modulus values 20 d post-PBS immersion, compared to dry conditions (Young's modulus = 1160 ± 290 kPa (dry) and 200 ± 120 kPa (20 d)). In addition to the two-dimensional (2D) elastomers, an integrative platform for accurate construction of three-dimensional tissue-mimicking models of cardiac anatomy from 2D MR images using rapid prototyping manufacturing processes was developed. For synthesized elastomers, doping strategies with two different concentrations of the MRI contrast agent Dotarem allowed independent and concurrent control of the imaging characteristics (contrast and relaxivity) during the synthetic process for increased contrast agent absorption, with tremendous potential for non-destructive in vivo use and applications to cardiovascular and cerebrovascular diseases. © 2012 IOP Publishing Ltd.en
dc.sourceBiomedical Materialsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84858994024&doi=10.1088%2f1748-6041%2f7%2f3%2f035006&partnerID=40&md5=0a7acbbedea33876269036f3e5a3be2c
dc.subjectmodelen
dc.subjectmethodologyen
dc.subjectarticleen
dc.subjecthumanen
dc.subjectHumansen
dc.subjectcontrolled studyen
dc.subjecthuman tissueen
dc.subjectunclassified drugen
dc.subjectnonhumanen
dc.subjectnuclear magnetic resonance imagingen
dc.subjectdrug derivativeen
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectanimalen
dc.subjectanimal tissueen
dc.subjectmouseen
dc.subjectphysiologyen
dc.subjectMagnetic resonance imagingen
dc.subjectchemistryen
dc.subjecthearten
dc.subjectPolymersen
dc.subjectcluster analysisen
dc.subjectCerebrovascular diseaseen
dc.subjectRapid prototypingen
dc.subjectLoadingen
dc.subjectsynthesisen
dc.subjectThree dimensionalen
dc.subjectCharacterizationen
dc.subjectAtomic force microscopyen
dc.subjectElastomersen
dc.subjectPlasticsen
dc.subjectTissueen
dc.subjectBiomechanicsen
dc.subjectElastic modulien
dc.subjectElasticityen
dc.subjectNanoindentationen
dc.subjectScanning electron microscopyen
dc.subjectYoung modulusen
dc.subjectmechanical stressen
dc.subjectpolymeren
dc.subjectContrast agenten
dc.subjectIn-vivoen
dc.subjectoscillationen
dc.subjectElastic Modulusen
dc.subjecttensile strengthen
dc.subjectBiomimetic Materialsen
dc.subjectmaterials testingen
dc.subjectMurinaeen
dc.subjectheart muscle cellen
dc.subjectstorageen
dc.subjectMolar ratioen
dc.subjectGlycerolen
dc.subjectPoly(glycerol sebacate)en
dc.subjectAFM nanoindentationen
dc.subjectAtomic force microscopies (AFM)en
dc.subjectbiomimetic materialen
dc.subjectBulk contributionsen
dc.subjectCardiac anatomyen
dc.subjectCluster formationsen
dc.subjectConcurrent controlen
dc.subjectDecanoatesen
dc.subjectdecanoic acid derivativeen
dc.subjectDoping strategiesen
dc.subjectDry conditionen
dc.subjectelastomeren
dc.subjectElastomeric materialsen
dc.subjectheart muscleen
dc.subjectHuman myocardiumen
dc.subjectImaging characteristicsen
dc.subjectLoading conditionen
dc.subjectLoading cyclesen
dc.subjectMechanical instabilitiesen
dc.subjectMorphological modelingen
dc.subjectMR imagesen
dc.subjectMRI contrast agentsen
dc.subjectMyocytes, Cardiacen
dc.subjectNon destructiveen
dc.subjectOscillatory responseen
dc.subjectPBS buffer solutionsen
dc.subjectphosphate buffered salineen
dc.subjectpoly(glycerol-sebacate)en
dc.subjectRapid-prototyping manufacturingen
dc.subjectRattusen
dc.subjectRelaxivityen
dc.subjectSample surfaceen
dc.subjectScanning electron microscopies (SEM)en
dc.subjectsebacic aciden
dc.subjectStress, Mechanicalen
dc.subjectSurface topologyen
dc.subjectSynthesized materialsen
dc.subjectSynthetic methodologyen
dc.subjectSynthetic processen
dc.subjecttissue characterizationen
dc.subjectTissue-mimicking materialsen
dc.subjectYoung's Modulusen
dc.titleMRI-based morphological modeling, synthesis and characterization of cardiac tissue-mimicking materialsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1088/1748-6041/7/3/035006
dc.description.volume7
dc.description.issue3
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :5</p>en
dc.source.abbreviationBiomed.Mater.(Bristol)en
dc.contributor.orcidPatrickios, Costas S. [0000-0001-8855-0370]
dc.contributor.orcidKafouris, Demetris [0000-0002-8566-8960]
dc.gnosis.orcid0000-0001-8855-0370
dc.gnosis.orcid0000-0002-8566-8960


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