Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
dc.contributor.author | Mpekris, F. | en |
dc.contributor.author | Angeli, S. | en |
dc.contributor.author | Pirentis, A. P. | en |
dc.contributor.author | Stylianopoulos, T. | en |
dc.creator | Mpekris, F. | en |
dc.creator | Angeli, S. | en |
dc.creator | Pirentis, A. P. | en |
dc.creator | Stylianopoulos, T. | en |
dc.date.accessioned | 2019-05-06T12:24:11Z | |
dc.date.available | 2019-05-06T12:24:11Z | |
dc.date.issued | 2015 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/48648 | |
dc.description.abstract | Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, thus, drastically reduce not only the supply of oxygen, but also the delivery of drugs at inner tumor regions. Among other effects, hypoxia and reduced drug delivery compromise the efficacy of radiation and chemo/nanotherapy, respectively. In the present study, we developed a mathematical model of tumor growth to investigate the interconnections among tumor oxygenation that supports cancer cell proliferation, the heterogeneous accumulation of mechanical stresses owing to tumor growth, the non-uniform compression of intratumoral blood vessels due to the mechanical stresses, and the insufficient delivery of oxygen and therapeutic agents because of vessel compression. We found that the high vascular density and increased cancer cell proliferation often observed in the periphery compared to the interior of a tumor can be attributed to heterogeneous solid stress accumulation. Highly vascularized peripheral regions are also associated with greater oxygenation compared with the compressed, less vascularized inner regions. We also modeled the delivery of drugs of two distinct sizes, namely chemotherapy and nanomedicine. Model predictions suggest that drug delivery is affected negatively by vessel compression independently of the size of the therapeutic agent. Finally, we demonstrated the applicability of our model to actual geometries, employing a breast tumor model derived from MR images. © 2015, Springer-Verlag Berlin Heidelberg. | en |
dc.language.iso | eng | en |
dc.source | Biomechanics and Modeling in Mechanobiology | en |
dc.subject | Mathematical models | en |
dc.subject | Models | en |
dc.subject | mathematical model | en |
dc.subject | conceptual framework | en |
dc.subject | antineoplastic agent | en |
dc.subject | Antineoplastic Agents | en |
dc.subject | human | en |
dc.subject | Breast Neoplasms | en |
dc.subject | controlled study | en |
dc.subject | cancer combination chemotherapy | en |
dc.subject | Chemotherapy | en |
dc.subject | Disease Progression | en |
dc.subject | priority journal | en |
dc.subject | solid tumor | en |
dc.subject | disease course | en |
dc.subject | clinical assessment | en |
dc.subject | biological model | en |
dc.subject | oxidative stress | en |
dc.subject | pathology | en |
dc.subject | Stress | en |
dc.subject | tumor growth | en |
dc.subject | vasculotropin | en |
dc.subject | nuclear magnetic resonance imaging | en |
dc.subject | Article | en |
dc.subject | Biological | en |
dc.subject | metabolism | en |
dc.subject | pathophysiology | en |
dc.subject | comparative study | en |
dc.subject | cancer cell | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal | en |
dc.subject | mouse | en |
dc.subject | Magnetic resonance imaging | en |
dc.subject | drug effects | en |
dc.subject | Tumor | en |
dc.subject | breast tumor | en |
dc.subject | Cell Line | en |
dc.subject | Hypoxia | en |
dc.subject | drug delivery system | en |
dc.subject | Cellular | en |
dc.subject | Cells | en |
dc.subject | Cytology | en |
dc.subject | computer simulation | en |
dc.subject | Stresses | en |
dc.subject | Oxygen | en |
dc.subject | Cell proliferation | en |
dc.subject | Tumors | en |
dc.subject | particle size | en |
dc.subject | Diseases | en |
dc.subject | Mathematical modeling | en |
dc.subject | blood vessel | en |
dc.subject | Mechanical | en |
dc.subject | Mechanotransduction | en |
dc.subject | Blood vessels | en |
dc.subject | Therapeutic agents | en |
dc.subject | mechanical stress | en |
dc.subject | blood vessel occlusion | en |
dc.subject | drug transport | en |
dc.subject | mechanotransduction | en |
dc.subject | Medical nanotechnology | en |
dc.subject | Medical imaging | en |
dc.subject | Heterogeneous solid | en |
dc.subject | Nanomedicine | en |
dc.subject | Non-uniform compression | en |
dc.subject | Oxygen supply | en |
dc.subject | Oxygenation | en |
dc.subject | Peripheral regions | en |
dc.subject | Radiation effects | en |
dc.subject | Tissue oxygenation | en |
dc.subject | Vessel collapse | en |
dc.subject | bioaccumulation | en |
dc.subject | cell density | en |
dc.subject | compression | en |
dc.subject | concentration response | en |
dc.subject | geometry | en |
dc.subject | metabolic clearance rate | en |
dc.subject | nanocarrier | en |
dc.subject | oxygen concentration | en |
dc.subject | oxygen consumption | en |
dc.subject | oxygen transport | en |
dc.subject | tumor cell line | en |
dc.subject | Tumor perfusion | en |
dc.subject | Vascular density | en |
dc.title | Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1007/s10237-015-0682-0 | |
dc.description.volume | 14 | |
dc.description.startingpage | 1391 | |
dc.description.endingpage | 1402 | |
dc.author.faculty | Πολυτεχνική Σχολή / Faculty of Engineering | |
dc.author.department | Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Stylianopoulos, T. [0000-0002-3093-1696] | |
dc.description.totalnumpages | 1391-1402 | |
dc.gnosis.orcid | 0000-0002-3093-1696 |
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