dc.contributor.author | Voutouri, C. | en |
dc.contributor.author | Stylianopoulos, T. | en |
dc.creator | Voutouri, C. | en |
dc.creator | Stylianopoulos, T. | en |
dc.date.accessioned | 2019-05-06T12:24:49Z | |
dc.date.available | 2019-05-06T12:24:49Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/48931 | |
dc.description.abstract | The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and experimentally. The magnitude and spatial distribution of osmotic pressures in tumors, however, cannot be measured experimentally and to our knowledge there is no mathematical model to calculate osmotic pressures in the tumor interstitial space. In this study, we developed a triphasic biomechanical model of tumor growth taking into account not only the solid and fluid phase of a tumor, but also the transport of cations and anions, as well as the fixed charges at the surface of the glycosaminoglycan chains. Our model predicts that the osmotic pressure is negligible compared to the interstitial fluid pressure for values of glycosaminoglycans (GAGs) taken from the literature for sarcomas, melanomas and adenocarcinomas. Furthermore, our results suggest that an increase in the hydraulic conductivity of the tumor, increases considerably the intratumoral concentration of free ions and thus, the osmotic pressure but it does not reach the levels of the interstitial fluid pressure. © 2014 Elsevier Ltd. | en |
dc.language.iso | eng | en |
dc.source | Journal of Biomechanics | en |
dc.subject | Mathematical models | en |
dc.subject | Models | en |
dc.subject | mathematical model | en |
dc.subject | human | en |
dc.subject | Neoplasms | en |
dc.subject | Humans | en |
dc.subject | controlled study | en |
dc.subject | cancer growth | en |
dc.subject | Disease Progression | en |
dc.subject | melanoma | en |
dc.subject | neoplasm | en |
dc.subject | sarcoma | en |
dc.subject | solid tumor | en |
dc.subject | disease course | en |
dc.subject | biological model | en |
dc.subject | carcinogenesis | en |
dc.subject | pathology | en |
dc.subject | Article | en |
dc.subject | adenocarcinoma | en |
dc.subject | Biological | en |
dc.subject | metabolism | en |
dc.subject | pathophysiology | en |
dc.subject | physiology | en |
dc.subject | predictive value | en |
dc.subject | Stresses | en |
dc.subject | mathematical computing | en |
dc.subject | Osmosis | en |
dc.subject | Tumors | en |
dc.subject | Interstitial fluid pressures | en |
dc.subject | osmotic pressure | en |
dc.subject | Biomechanical Phenomena | en |
dc.subject | extracellular fluid | en |
dc.subject | spatial analysis | en |
dc.subject | tissue pressure | en |
dc.subject | Transport properties | en |
dc.subject | Microenvironments | en |
dc.subject | Tumor microenvironment | en |
dc.subject | phase transition | en |
dc.subject | hydraulic conductivity | en |
dc.subject | biomechanics | en |
dc.subject | tumor model | en |
dc.subject | Interstitial space | en |
dc.subject | anion transport | en |
dc.subject | Bio-mechanical models | en |
dc.subject | Cancer progression | en |
dc.subject | carbohydrate analysis | en |
dc.subject | cation transport | en |
dc.subject | Charged density | en |
dc.subject | Donnan osmotic pressure | en |
dc.subject | Fixed charged density | en |
dc.subject | glycosaminoglycan | en |
dc.subject | Glycosaminoglycans | en |
dc.subject | interstitium | en |
dc.subject | Tumor mechanics | en |
dc.title | Evolution of osmotic pressure in solid tumors | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.jbiomech.2014.09.019 | |
dc.description.volume | 47 | |
dc.description.startingpage | 3441 | |
dc.description.endingpage | 3447 | |
dc.author.faculty | Πολυτεχνική Σχολή / Faculty of Engineering | |
dc.author.department | Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Stylianopoulos, T. [0000-0002-3093-1696] | |
dc.description.totalnumpages | 3441-3447 | |
dc.gnosis.orcid | 0000-0002-3093-1696 | |