dc.contributor.author | Birol, O. | en |
dc.contributor.author | Ohyama, T. | en |
dc.contributor.author | Edlund, R. K. | en |
dc.contributor.author | Drakou, Katerina | en |
dc.contributor.author | Georgiades, Pantelis | en |
dc.contributor.author | Groves, A. K. | en |
dc.creator | Birol, O. | en |
dc.creator | Ohyama, T. | en |
dc.creator | Edlund, R. K. | en |
dc.creator | Drakou, Katerina | en |
dc.creator | Georgiades, Pantelis | en |
dc.creator | Groves, A. K. | en |
dc.date.accessioned | 2019-11-04T12:50:15Z | |
dc.date.available | 2019-11-04T12:50:15Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/52950 | |
dc.description.abstract | The inner ear develops from the otic placode, one of the cranial placodes that arise from a region of ectoderm adjacent to the anterior neural plate called the pre-placodal domain. We have identified a Forkhead family transcription factor, Foxi3, that is expressed in the pre-placodal domain and down-regulated when the otic placode is induced. We now show that Foxi3 mutant mice do not form otic placodes as evidenced by expression changes in early molecular markers and the lack of thickened placodal ectoderm, an otic cup or otocyst. Some preplacodal genes downstream of Foxi3-Gata3, Six1 and Eya1-are not expressed in the ectoderm of Foxi3 mutant mice, and the ectoderm exhibits signs of increased apoptosis. We also show that Fgf signals from the hindbrain and cranial mesoderm, which are necessary for otic placode induction, are received by pre-placodal ectoderm in Foxi3 mutants, but do not initiate otic induction. Finally, we show that the epibranchial placodes that develop in close proximity to the otic placode and the mandibular division of the trigeminal ganglion are missing in Foxi3 mutants. Our data suggest that Foxi3 is necessary to prime pre-placodal ectoderm for the correct interpretation of inductive signals for the otic and epibranchial placodes. © 2015 Elsevier Inc. | en |
dc.source | Developmental biology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960942720&doi=10.1016%2fj.ydbio.2015.09.022&partnerID=40&md5=11f262245feefd2178e9a2f97e2a3633 | |
dc.subject | controlled study | en |
dc.subject | priority journal | en |
dc.subject | gene | en |
dc.subject | genotype | en |
dc.subject | immunohistochemistry | en |
dc.subject | protein expression | en |
dc.subject | unclassified drug | en |
dc.subject | down regulation | en |
dc.subject | gene expression regulation | en |
dc.subject | nonhuman | en |
dc.subject | signal transduction | en |
dc.subject | Article | en |
dc.subject | metabolism | en |
dc.subject | biological marker | en |
dc.subject | apoptosis | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal | en |
dc.subject | animal tissue | en |
dc.subject | mouse | en |
dc.subject | genetics | en |
dc.subject | molecular marker | en |
dc.subject | mutation | en |
dc.subject | wild type | en |
dc.subject | Biomarkers | en |
dc.subject | Down-Regulation | en |
dc.subject | embryo | en |
dc.subject | protein domain | en |
dc.subject | Gene Expression Regulation, Developmental | en |
dc.subject | Craniofacial Placodes | en |
dc.subject | development | en |
dc.subject | ectoderm | en |
dc.subject | Embryo, Mammalian | en |
dc.subject | embryology | en |
dc.subject | epidermis | en |
dc.subject | Eya1 gene | en |
dc.subject | FGF | en |
dc.subject | fibroblast growth factor | en |
dc.subject | Fibroblast Growth Factors | en |
dc.subject | forkhead transcription factor | en |
dc.subject | Forkhead Transcription Factors | en |
dc.subject | Foxi3 gene | en |
dc.subject | Foxi3 protein, mouse | en |
dc.subject | Gata3 gene | en |
dc.subject | inner ear | en |
dc.subject | mammalian embryo | en |
dc.subject | mesoderm | en |
dc.subject | mouse mutant | en |
dc.subject | nervous system development | en |
dc.subject | Neurogenesis | en |
dc.subject | Otic Placode | en |
dc.subject | Pax2 protein, mouse | en |
dc.subject | PAX2 Transcription Factor | en |
dc.subject | posterior placode | en |
dc.subject | Pre-placodal induction | en |
dc.subject | protein Foxi3 | en |
dc.subject | rhombencephalon | en |
dc.subject | Six1 gene | en |
dc.subject | transcription factor GATA 3 | en |
dc.subject | transcription factor PAX2 | en |
dc.subject | transcription factor Six1 | en |
dc.subject | trigeminus ganglion | en |
dc.title | The mouse Foxi3 transcription factor is necessary for the development of posterior placodes | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.ydbio.2015.09.022 | |
dc.description.volume | 409 | |
dc.description.startingpage | 139 | |
dc.description.endingpage | 151 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :2</p> | en |
dc.source.abbreviation | Dev.Biol. | en |
dc.contributor.orcid | Georgiades, Pantelis [0000-0002-5538-3163] | |
dc.gnosis.orcid | 0000-0002-5538-3163 | |