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dc.contributor.authorJain, R. K.en
dc.contributor.authorMartin, J. D.en
dc.contributor.authorStylianopoulos, T.en
dc.creatorJain, R. K.en
dc.creatorMartin, J. D.en
dc.creatorStylianopoulos, T.en
dc.date.accessioned2019-05-06T12:23:45Z
dc.date.available2019-05-06T12:23:45Z
dc.date.issued2014
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48436
dc.description.abstractTumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase cells' invasive and metastatic potential. Tumor vessels- while nourishing the tumor-are usually leaky and tortuous, which further decreases perfusion.Hypoperfusion and hypoxia contribute to immune evasion, promote malignant progression and metastasis, and reduce the efficacy of a number of therapies, including radiation. In parallel, vessel leakiness together with vessel compression causes a uniformly elevated interstitial fluid pressure that hinders delivery of blood-borne therapeutic agents, lowering the efficacy of chemo- and nanotherapies. In addition, shear stresses exerted by flowing blood and interstitial fluid modulate the behavior of cancer and a variety of host cells. Taming these physical forces can improve therapeutic outcomes in many cancers. Copyright © 2014 by Annual Reviews. All rights reserved.en
dc.language.isoengen
dc.sourceAnnual Review of Biomedical Engineeringen
dc.subjectModelsen
dc.subjecttheoretical modelen
dc.subjectTheoreticalen
dc.subjecthumanen
dc.subjectNeoplasmsen
dc.subjectHumansen
dc.subjectDisease Progressionen
dc.subjectreviewen
dc.subjectmetastasisen
dc.subjectNeoplasm Metastasisen
dc.subjecttumor microenvironmenten
dc.subjectdisease courseen
dc.subjectrectum canceren
dc.subjectnonhumanen
dc.subjectpathologyen
dc.subjectStressen
dc.subjecttumor growthen
dc.subjecttumor vascularizationen
dc.subjectbevacizumaben
dc.subjectdrug mechanismen
dc.subjectpancreas canceren
dc.subjectpathophysiologyen
dc.subjectAnimalsen
dc.subjectanimalen
dc.subjectimmune systemen
dc.subjectcancer resistanceen
dc.subjectcell invasionen
dc.subjecthypoxiaen
dc.subjecttreatment failureen
dc.subjectchemistryen
dc.subjectVascular Endothelial Growth Factor Aen
dc.subjectvasculotropin Aen
dc.subjectmetastasis potentialen
dc.subjectBlooden
dc.subjectdrug delivery systemen
dc.subjectDrug Delivery Systemsen
dc.subjectdipeptidyl carboxypeptidase inhibitoren
dc.subjectglioblastomaen
dc.subjectTumorsen
dc.subjectDiseasesen
dc.subjectextracellular fluiden
dc.subjecttissue pressureen
dc.subjectperfusionen
dc.subjectlosartanen
dc.subjectMechanicalen
dc.subjectBlood vesselsen
dc.subjectmonoclonal antibody DC101en
dc.subjectangiogenesis inhibitoren
dc.subjecttumor blood flowen
dc.subjectblood vessel permeabilityen
dc.subjectmechanical stressen
dc.subjectstress alleviationen
dc.subjecttumor perfusionen
dc.subjectvascular normalizationen
dc.subjectangiotensin receptor antagonisten
dc.subjectanoxiaen
dc.subjectblood vessel occlusionen
dc.subjectcediraniben
dc.subjectEnzyme inhibitionen
dc.subjectforceen
dc.subjectimmune evasionen
dc.subjectlymphen
dc.subjectlymphatic systemen
dc.subjectmicrocirculationen
dc.subjectsaridegiben
dc.subjectshear strengthen
dc.subjectshear stressen
dc.subjectsolid stressen
dc.subjecttissue perfusionen
dc.subjectvascular hyperpermeabilityen
dc.subjectvasculotropin inhibitoren
dc.subjectvessel compressionen
dc.titleThe role of mechanical forces in tumor growth and therapyen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1146/annurev-bioeng-071813-105259
dc.description.volume16
dc.description.startingpage321
dc.description.endingpage346
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.description.totalnumpages321-346


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