dc.contributor.author | Wijeratne, P. A. | en |
dc.contributor.author | Vavourakis, V. | en |
dc.contributor.author | Hipwell, J. H. | en |
dc.contributor.author | Voutouri, C. | en |
dc.contributor.author | Papageorgis, P. | en |
dc.contributor.author | Stylianopoulos, T. | en |
dc.contributor.author | Evans, A. | en |
dc.contributor.author | Hawkes, D. J. | en |
dc.creator | Wijeratne, P. A. | en |
dc.creator | Vavourakis, V. | en |
dc.creator | Hipwell, J. H. | en |
dc.creator | Voutouri, C. | en |
dc.creator | Papageorgis, P. | en |
dc.creator | Stylianopoulos, T. | en |
dc.creator | Evans, A. | en |
dc.creator | Hawkes, D. J. | en |
dc.date.accessioned | 2019-05-06T12:24:49Z | |
dc.date.available | 2019-05-06T12:24:49Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/48934 | |
dc.description.abstract | Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. We hypothesise that such a model, which provides a purely mechanical description of tumour–host interactions, can be used to explain experimental observations of the effect of collagen micromechanics on solid tumour growth. The model was specified to mouse tumour data, and numerical simulations were performed. The multiscale model produced lower stresses than an equivalent continuum-like approach, due to a more realistic remodelling of the collagen microstructure. Furthermore, solid tumour growth was found to cause a passive mechanical realignment of fibres at the tumour boundary from a random to a circumferential orientation. This is in accordance with experimental observations, thus demonstrating that such a response can be explained as purely mechanical. Finally, peritumoural fibre network anisotropy was found to produce anisotropic tumour morphology. The dependency of tumour morphology on the peritumoural microstructure was reduced by adding a load-bearing non-collagenous component to the fibre network constitutive equation. © 2015, Springer-Verlag Berlin Heidelberg. | en |
dc.language.iso | eng | en |
dc.source | Biomechanics and Modeling in Mechanobiology | en |
dc.subject | Models | en |
dc.subject | Algorithms | en |
dc.subject | human | en |
dc.subject | Neoplasms | en |
dc.subject | Humans | en |
dc.subject | controlled study | en |
dc.subject | algorithm | en |
dc.subject | priority journal | en |
dc.subject | tumor volume | en |
dc.subject | tumor microenvironment | en |
dc.subject | neoplasm | en |
dc.subject | solid tumor | en |
dc.subject | biological model | en |
dc.subject | cell proliferation | en |
dc.subject | nonhuman | en |
dc.subject | pathology | en |
dc.subject | Stress | en |
dc.subject | tumor growth | en |
dc.subject | Article | en |
dc.subject | Biological | en |
dc.subject | metabolism | en |
dc.subject | human cell | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | animal | en |
dc.subject | animal experiment | en |
dc.subject | animal tissue | en |
dc.subject | mouse | en |
dc.subject | Collagen | en |
dc.subject | Tumor | en |
dc.subject | Cell Line | en |
dc.subject | simulation | en |
dc.subject | Tumor Burden | en |
dc.subject | computer simulation | en |
dc.subject | Finite element method | en |
dc.subject | Fibers | en |
dc.subject | Microstructure | en |
dc.subject | Anisotropy | en |
dc.subject | Tumors | en |
dc.subject | Biomechanical Phenomena | en |
dc.subject | Finite element analysis | en |
dc.subject | Mechanical | en |
dc.subject | Microenvironments | en |
dc.subject | kinematics | en |
dc.subject | mechanical stress | en |
dc.subject | tumor cell line | en |
dc.subject | biomechanics | en |
dc.subject | collagen fiber | en |
dc.subject | Equivalent continuum | en |
dc.subject | Excitons | en |
dc.subject | Fibre interactions | en |
dc.subject | Fibre network | en |
dc.subject | Fibre remodelling | en |
dc.subject | Host interactions | en |
dc.subject | Microenvironment | en |
dc.subject | Micromechanics | en |
dc.subject | Multi-scale Modeling | en |
dc.subject | Multi-scale modelling | en |
dc.subject | Tumour growth | en |
dc.subject | Tumour mechanics | en |
dc.title | Multiscale modelling of solid tumour growth: the effect of collagen micromechanics | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1007/s10237-015-0745-2 | |
dc.description.volume | 15 | |
dc.description.startingpage | 1079 | |
dc.description.endingpage | 1090 | |
dc.author.faculty | Πολυτεχνική Σχολή / Faculty of Engineering | |
dc.author.department | Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Stylianopoulos, T. [0000-0002-3093-1696] | |
dc.description.totalnumpages | 1079-1090 | |
dc.gnosis.orcid | 0000-0002-3093-1696 | |